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首页> 外文期刊>Diabetes technology & therapeutics >Differences for Percentage Times in Glycemic Range Between Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring in Adults with Type 1 Diabetes: Analysis of the REPLACE-BG Dataset
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Differences for Percentage Times in Glycemic Range Between Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring in Adults with Type 1 Diabetes: Analysis of the REPLACE-BG Dataset

机译：1型糖尿病患者连续葡萄糖监测和毛细血管血糖监测的血糖范围百分比的差异：替换BG数据集分析

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Background: Self-monitored blood glucose (SMBG) and real-time continuous glucose monitoring (rtCGM) are used by people living with type 1 diabetes (T1D) to assess glucose and inform decision-making. Percentage time in range (%TIR) between 3.9 and 10 mmol/L has been associated with incident microvascular complications using historical SMBG data. However, the association between %TIR calculated from rtCGM data has not been identified. This study investigates whether %TIR values generated from rtCGM and SMBG data significantly differ from each other in adults with T1D. Materials and Methods: rtCGM and SMBG data from the REPLACE-BG study were obtained and analyzed. The dataset contained rtCGM (Dexcom G4 Platinum) and SMBG (Contour Next) values for 226 participants during a run-in phase lasting up to 10 weeks, followed by the 26-week trial. Percentages times in hypoglycemic, euglycemia and hyperglycemic ranges were generated from rtCGM and SMBG data using last observation carry forward method (zero-order hold) and linear interpolation (first-order hold). Results: Participants had a median (interquartile range [IQR]) age of 43.0 (31.0-55.0) years, and hemoglobin A1C of 53 (49-57) mmol/mol [7.0 (6.6-7.4)%]. The median (IQR) %TIR was significantly higher with rtCGM than with SMBG; 63.0 (55.9-71.0)% versus 54.6 (45.6-63.0)%, respectively, P < 0.001. Median %times in hypoglycemia and hyperglycemia were significantly different with SMBG than rtCGM (P < 0.001). SMBG-derived data using linear interpolation significantly differed from the carry forward method (P < 0.001 for all glycemic ranges). Differences reported were greater at night than during the day (P < 0.001 for all glycemic ranges). Conclusion: The %time in all glycemic ranges reported by SMBG and rtCGM differ significantly, suggesting relationships between times in ranges, and complication status may be different between monitoring modalities. In addition, varying methods of calculating %TIR from SMBG-derived data provide significantly differing results. %TIR targets may therefore vary by monitoring choice and methods of calculation and harmonization of TIR standards may be challenging.
机译：背景：自我监测血糖（SMBG）和实时连续葡萄糖监测（RTCGM）用于患有1型糖尿病（T1D）以评估葡萄糖并提供信息。 3.9和10mmol / L之间的范围（％TIR）的百分比时间与使用历史SMBG数据的入射微血管并发症相关。然而，尚未识别从RTCGM数据计算的％TIR之间的关联。本研究研究了从RTCGM和SMBG数据产生的％TIR值是否在具有T1D的成年人中彼此显着不同。材料和方法：获得并分析来自替换BG研究的RTCG和SMBG数据。数据集在持续10周后的持续阶段期间包含226名参与者的RTCGM（DEXCOM G4铂）和SMBG（轮廓下一个）值，其次是26周的试验。从RTCGM和使用上一次观察的RTCGM和SMBG数据生成次血糖，晚期和高血糖范围的百分比次数，进入方法（零阶保持）和线性插值（一阶保持）。结果：参与者有一个中位数（句子范围）43.0（31.0-55.0）年龄（31.0-55.0）岁，血红蛋白A1C为53（49-57）mmol / mol [7.0（6.6-7.4）％]。 RTCGM中位数（IQR）％TIR比SMBG显着更高; 63.0（55.9-71.0）％分别为54.6（45.6-63.0）％，p <0.001。低血糖和高血糖中的中位数次数与SMBG显着不同（P <0.001）。使用线性插值的SMBG衍生数据与进载方法显着不同（所有血糖范围的P <0.001）。报告的差异在晚上比白天更大（所有血糖范围的P <0.001）。结论：SMBG和RTCG报告的所有血糖范围内的含量显着差异，表明在范围内的时间和并发症状态之间的关系在监测模式之间可能存在不同。此外，从SMBG衍生数据计算％TIR的变化方法提供了显着不同的结果。因此，％TIR目标可能因监测选择和计算方法和统一标准的方法而变化可能是具有挑战性的。

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