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首页> 外文期刊>Journal of cellular biochemistry. >Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer
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Flavonoid silybin improves the response to radiotherapy in invasive bladder cancer

机译：黄酮类甲硅柳树在侵袭性膀胱癌中改善了对放射治疗的反应

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Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo‐radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Silybin (Sb) inhibits pathways involved in cell survival and resistance mechanisms, therefore the purpose of this paper was to study in vitro and in vivo, the ability of Sb to improve the response to RT, in two murine BC cell lines, with different levels of invasiveness, placing emphasis on radio‐sensitivity, and pathways involved in radio‐resistance and survival. In vitro, Sb radio‐sensitized murine invasive cells through the inhibition of RT‐induced NF‐κB and PI3K pathways, and the increase of oxidative stress, while non‐invasive cells did not show to be sensitized. In vivo, Sb improved RT‐response and overall survival in invasive murine tumors. As Sb is already being tested in clinical trials for other urological cancers and it improves RT‐response in invasive BC, these results could have translational relevance, supporting further research.
机译：侵袭性膀胱癌（BC）的保守治疗涉及完整的经尿道肿瘤切除，与化疗（CT）和放射疗法（RT）联合。化学放射疗法的主要障碍是添加RT和CT的毒性，并且由于RT和CT电阻而重复性。类黄酮鳞片（Sb）抑制涉及细胞存活和抗性机制的途径，因此本文的目的是在体外和体内研究，Sb改善对rt的反应，在两只小鼠BC细胞中，具有不同水平的侵袭性，强调无线电敏感性，以及参与无线电抗性和生存的途径。通过抑制RT诱导的NF-κB和PI3K途径，在体外，Sb无线电敏化鼠侵袭性细胞，以及氧化应激的增加，而非侵入性细胞没有显示出敏化。体内，SB改善了侵袭性鼠肿瘤的RT-反应和整体存活。由于SB已经在其他泌尿科癌症的临床试验中进行测试，并且它改善了侵袭性BC的RT-反应，这些结果可以具有平移相关性，支持进一步的研究。

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