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首页> 外文期刊>American Journal of Perinatology >Comparison of urinary cytokines after ingestion of cranberry juice cocktail in pregnant subjects: a pilot study.
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Comparison of urinary cytokines after ingestion of cranberry juice cocktail in pregnant subjects: a pilot study.

机译：孕妇摄入蔓越莓汁鸡尾酒后尿细胞因子的比较：一项前瞻性研究。

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摘要

Our objective was to evaluate urinary cytokine excretion after daily cranberry or placebo exposure in pregnant women. Four-hour urine samples were collected from 27 pregnant women subjects who were randomized to cranberry juice cocktail or placebo in three treatment arms: A: Cranberry (C) two times daily (C, C; n = 10 pregnant); B: cranberry in the AM, then placebo (P) in the PM (C, P; n = 9 pregnant); and C: placebo two times daily (P, P; n = 8 pregnant). Urinary cytokines were measured using commercially available kits. There was a statistically significant difference in interleukin (IL)-6 of the urinary cytokines between the multiple daily cranberry dosing group (group A [C, C]): median, 3.16 (range, 0.01 to 7.34) and the placebo group (group C [P, P]): 9.32 (0.53 to 29.61 pg/mL; p = 0.038, Kruskal-Wallis test). We concluded that a difference in IL-6 was found in the multiple daily cranberry dosing groups compared with placebo. Lack of differences based on treatment allocation in the other cytokines may be due to beta error. Further studies are planned to evaluate these assays for the assessment of clinical effect.
机译：我们的目标是评估孕妇每天蔓越莓或安慰剂暴露后尿细胞因子的排泄情况。从27名孕妇受试者中收集四小时尿液样本，这些受试者在三个治疗组中被随机分配到酸果蔓汁鸡尾酒或安慰剂中：A：蔓越莓（C）每天两次（C，C; n = 10怀孕）; B：AM中的蔓越莓，PM中的安慰剂（P）（C，P; n = 9怀孕）; C：每天两次安慰剂（P，P; n = 8怀孕）。使用市售试剂盒测量尿液细胞因子。每天多次蔓越莓给药组（A组[C，C]）之间尿液细胞因子的白介素（IL）-6差异有统计学意义：中位数为3.16（范围为0.01至7.34），安慰剂组为C [P，P]）：9.32（0.53至29.61 pg / mL; p = 0.038，Kruskal-Wallis试验）。我们得出的结论是，与安慰剂相比，每天多次蔓越莓给药组的IL-6有所不同。其他细胞因子基于治疗分配的差异缺乏可能是由于β错误。计划进行进一步的研究以评估这些测定法，以评估临床效果。

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