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首页> 外文期刊>American Journal of Obstetrics and Gynecology >Cerebral white matter lesions and perceived cognitive dysfunction: The role of pregnancy
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Cerebral white matter lesions and perceived cognitive dysfunction: The role of pregnancy

机译：脑白质病变和认知功能障碍：怀孕的作用

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摘要

Objective Women who suffered eclampsia or preterm preeclampsia are twice as likely to demonstrate cerebral white matter lesions (WML) on magnetic resonance imaging compared with age-matched women who had normotensive pregnancies, and they report more cognitive dysfunctions in everyday life. We aimed to determine whether pregnancy in and of itself has a relationship with the presence of WML and subjective cognitive dysfunction. Study Design Eighty-one parous women who had a normotensive pregnancy were matched for age with 65 nulliparous women and all underwent cerebral magnetic resonance imaging. Presence of cerebral WML was rated and blood pressure was measured. Subjective cognitive functioning was assessed using the Cognitive Failures Questionnaire. Results There was no difference in the presence (22% vs 19%) of WML between parous and nulliparous women. Age was a predictor for the presence of WML, whereas the presence of current hypertension was not. Average score on the Cognitive Failures Questionnaire was not different between both groups, nor related to WML. Conclusion A history of pregnancy in and of itself is not related to the presence of cerebral WML and the perception of cognitive dysfunction. Because of the relationship with preterm preeclampsia and eclampsia, future research should focus on the clinical importance and development throughout the years of such cerebral WML in young women and focus on risk factors for cardiovascular disease.
机译：目的患有子痫或早发先兆子痫的女性在磁共振成像上显示脑白质病变（WML）的可能性是正常血压妊娠的同龄女性的两倍，而且她们在日常生活中的认知功能障碍也更多。我们旨在确定妊娠本身是否与WML的存在和主观认知功能障碍有关。研究设计将正常血压妊娠的81名产妇与65名未产妇进行了年龄匹配，并且均接受了脑磁共振成像。评估了脑WML的存在并测量了血压。使用认知障碍问卷评估主观认知功能。结果产妇和未产妇中WML的存在率没有差异（分别为22％和19％）。年龄是WML存在的预测因素，而当前的高血压并非如此。两组认知障碍问卷的平均得分没有差异，也与WML无关。结论妊娠史本身与脑WML的存在和认知功能障碍的认识无关。由于与早产先兆子痫和子痫的关系，未来的研究应着重于这类脑WML在年轻女性中的临床重要性和发展，并着重于心血管疾病的危险因素。

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