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首页> 外文期刊>American journal of psychiatry >Neuropsychological impairments in schizophrenia and psychotic Bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study
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Neuropsychological impairments in schizophrenia and psychotic Bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study

机译：精神分裂症和精神病性双相情感障碍的神经心理学障碍：双相精神分裂症网络中型表型（B-SNIP）研究的发现

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Objective: Familialneuropsychologicaldeficits are well established in schizophrenia but remain less well characterized in other psychotic disorders. This study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares cognitive impairment in schizophrenia and bipolar disorder with psychosis, 2) tests a continuum model of cognitive dysfunction in psychotic disorders, 3) reports familiality of cognitive impairments across psychotic disorders, and 4) evaluates cognitive impairment among nonpsychotic relatives with and without cluster A personality traits. Method: Participants included probands with schizophrenia (N=293), psychotic bipolar disorder (N=227), schizoaffective disorder (manic, N=110; depressed, N=55), their first-degree relatives (N=316, N=259, N=133, and N=64, respectively), and healthy comparison subjects (N=295). All participants completed the Brief Assessment of Cognition in Schizophrenia (BACS) neuropsychological battery. Results: Cognitive impairments among psychotic probands, compared to healthy comparison subjects, were progressively greater from bipolar disorder (z=-0.77) to schizoaffective disorder (manic z=-1.08; depressed z=-1.25) to schizophrenia (z=-1.42). Profiles across subtests of the BACS were similar across disorders. Familiality of deficits was significant and comparable in schizophrenia and bipolar disorder. Of particular interest were similar levels of neuropsychological deficits in relatives with elevated cluster A personality traits across proband diagnoses. Nonpsychotic relatives of schizophreniaprobands without these personality traits exhibited significant cognitive impairments, while relatives of bipolar probands did not. Conclusions: Robust cognitive deficits are present and familial in schizophrenia and psychotic bipolar disorder. Severity of cognitive impairments across psychotic disorders was consistent with a continuum model, in which more prominent affective features and less enduring psychosis were associated with less cognitive impairment. Cognitive dysfunction in firstdegree relatives is more closely related to psychosis-spectrum personality disorder traits in psychotic bipolar disorder than in schizophrenia.
机译：目的：精神分裂症中的家族性神经心理缺陷已得到很好的确立，但在其他精神病性疾病中仍表现得较差。来自双相精神分裂症中间表型网络（B-SNIP）联盟的这项研究1）比较精神分裂症和患有精神病的双相情感障碍的认知障碍，2）测试精神病障碍的认知功能障碍的连续模型，3）报告认知障碍的家族性（4）评估具有或不具有A组性格特征的非精神病亲戚的认知障碍。方法：参与者包括精神分裂症（N = 293），精神病性双相情感障碍（N = 227），精神分裂性情感障碍（躁狂症，N = 110;抑郁症，N = 55）及其一级亲属（N = 316）的先证者。分别为259，N = 133和N = 64）和健康的比较对象（N = 295）。所有参与者均完成了对精神分裂症（BACS）神经心理学知识的简短评估。结果：与健康比较对象相比，精神病先证者的认知障碍从躁郁症（z = -0.77）到情感分裂性障碍（躁狂症z = -1.08;抑郁症z = -1.25）到精神分裂症（z = -1.42）逐渐增加。在各种疾病中，BACS子测试的概况相似。精神分裂症和双相情感障碍的缺陷家族性是重要的，可比。特别令人感兴趣的是，在先证者诊断中，伴有簇A人格特征升高的亲戚的神经心理缺陷水平相似。没有这些人格特质的精神分裂症先证者的非精神病亲属表现出明显的认知障碍，而双相先证者的亲属则没有。结论：精神分裂症和精神病性双相情感障碍存在明显的家族性认知缺陷，并且家族性。跨精神病性障碍的认知障碍的严重程度与连续性模型一致，在该模型中，较突出的情感特征和较少的持久性精神病与较少的认知障碍相关。与精神分裂症相比，精神病双相情感障碍中一级亲属的认知功能障碍与精神病-谱人格障碍特征更密切相关。

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