Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

Goriely S; Cavoy R; Goldman M

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Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

机译：Th17介导的炎症性疾病中的白细胞介素12家族成员和I型干扰素。

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Cytokines produced by antigen-presenting cells govern the fate of helper T-cell responses. Herein, we review the impact of interleukin (IL)-23 and IL-27 on the outcome of T-helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T-cell-mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL-12 family members.

机译：抗原呈递细胞产生的细胞因子决定着辅助性T细胞反应的命运。在本文中，我们综述了白介素（IL）-23和IL-27对T辅助（Th）17细胞应答结果的影响，并讨论了它们在T细胞介导的自身免疫性或变应性炎性疾病发病机理中的影响。然后，我们通过提示IL-12家庭成员之间的平衡来讨论I型干扰素如何影响自身免疫疾病的进程。

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《Allergy》 |2009年第5期|共8页
作者
Goriely S; Cavoy R; Goldman M;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Interleukin-12; Family Members; T-Lymphocytes; Pathogenesis; 白细胞介素12; T淋巴细胞;

机译：Interleukin-12;Family Members;T-Lymphocytes;Pathogenesis;白细胞介素12;T淋巴细胞;

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专利

1. Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders. [J] . Goriely S, Cavoy R, Goldman M Allergy . 2009,第5期

机译：Th17介导的炎症性疾病中的白细胞介素12家族成员和I型干扰素。
2. Interferon-beta exacerbates Th17-mediated inflammatory disease. [J] . Axtell RC, Raman C, Steinman L Trends in immunology . 2011,第6期

机译：β-干扰素加剧了Th17介导的炎症性疾病。
3. Endogenous, or therapeutically induced, type i interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS [J] . KalinkeU., PrinzM. Immunology and Cell Biology . 2012,第5期

机译：内源性或治疗性诱导的I型干扰素反应差异调节中枢神经系统中Th1 / Th17介导的自身免疫
4. IRF family transcription factors in type I interferon induction [C] . Hideyuki Yanai, Tatsuaki Mizutani, Takayuki Inuzuka, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：ISF系列转录因子I型干扰素诱导
5. The role of type I interferons in T helper cell inflammatory responses in systemic lupus erythematosus. [D] . Mangini, Alyson J. 2011

机译：I型干扰素在系统性红斑狼疮T辅助细胞炎症反应中的作用。
6. Endogenous or therapeutically induced type I interferon responses differentially modulate Th1/Th17-mediated autoimmunity in the CNS [O] . Ulrich Kalinke, Marco Prinz -1

机译：内源性或治疗诱导的I型干扰素应答差异性调节中枢神经系统中Th1 / Th17介导的自身免疫
7. Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders. [O] . Goriely Stanislas, Cavoy Rani, Goldman Michel 2009

机译：Th17介导的炎症性疾病中的白细胞介素12家族成员和I型干扰素。
8. Optogenetic Stimulation of Peripheral Vagus Nerves using Flexible OLED Display Technology to Treat Chronic Inflammatory Disease and Mental Health Disorders. [R] . Smith, J. T., Shah, A., Lee, Y., 2016

机译：利用柔性OLED显示技术治疗慢性炎症和心理健康疾病的外周迷走神经的光遗传学刺激。

Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

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