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首页> 外文期刊>Allergy >Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis.
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Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis.

机译：功能性内窥镜鼻窦手术可改善鼻息肉病患者的哮喘症状以及PEFR和嗅觉。

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BACKGROUND: Nasal polyposis is a disease known to be associated with asthma. The management is anti-inflammatory, with topical and oral corticosteroids as the first-line treatment. The effect of surgical treatment on lower airway inflammation has not been sufficiently studied. AIM: The aim of this study is to investigate the effects of functional endoscopic sinus surgery (FESS) as well as fluticasone proprionate nasal drops (FPND) 400 microg b.i.d. on nasal and lower airway parameters in asthmatics with nasal polyposis. METHODS: This was a prospective 21-week study of 68 patients with asthma and nasal polyposis, on the benefits of FESS on nasal '(butanol test, subjective olfaction, peak nasal inspiratory flow, congestion, rhinorrhoea, and polyp score)', and on the lower airway parameters (dyspnea, cough, mean daily peak expiratory flow rate (PEFR), and lung function tests). It also included a randomized, double-blind, placebo-controlled 14 weeks phase on FPND. RESULTS: Functional endoscopic sinus surgery significantly improved mean asthma symptom scores and daily PEFR and all nasal parameters including subjective and objective olfaction tests. This is the first study that shows the benefits of FESS on butanol tests in patients with nasal polyposis. We found no significant difference between topical treatment with FPND or placebo in the nasal or lower airway variables. CONCLUSION: Functional endoscopic sinus surgery improved nasal and asthma symptoms in patients with nasal polyposis. Functional endoscopic sinus surgery could be considered early in the natural course of nasal polyposis with concomitant asthma, as well as a second-line treatment in nasal polyposis patients with a reduced sense of smell. The potential benefits of FPND 400 microg b.i.d. were probably overshadowed by FESS.
机译：背景：鼻息肉病是一种已知与哮喘有关的疾病。治疗是抗炎的，外用和口服皮质类固醇作为一线治疗。尚未充分研究手术治疗对下呼吸道炎症的影响。目的：本研究的目的是研究功能性内窥镜鼻窦手术（FESS）以及丙酸氟替卡松滴鼻液（FPND）400 microg b.i.d.鼻息肉病患者鼻和下呼吸道参数的变化方法：这是一项对68名哮喘和鼻息肉病患者进行的为期21周的前瞻性研究，研究了FESS对鼻部的好处（“丁醇测试，主观嗅觉，鼻吸气峰值，充血，鼻涕和息肉评分）”，以及较低的气道参数（呼吸困难，咳嗽，平均每日最大呼气流速（PEFR）和肺功能测试）。它还包括在FPND上进行的随机，双盲，安慰剂对照的14周试验。结果：功能性内窥镜鼻窦手术显着改善了平均哮喘症状评分和每日PEFR以及所有鼻参数，包括主观和客观嗅觉测试。这是第一项显示FESS对鼻息肉病患者丁醇测试有益的研究。我们发现在鼻腔或下呼吸道变量中使用FPND或安慰剂进行局部治疗之间无显着差异。结论：功能性内窥镜鼻窦手术可改善鼻息肉病患者的鼻和哮喘症状。在伴有哮喘的鼻息肉自然病程中，可以考虑早期进行功能性内窥镜鼻窦手术，以及对鼻息肉病患者降低嗅觉的二线治疗。 FPND 400 microg b.i.d.的潜在好处可能被FESS所蒙蔽。

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