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首页> 外文期刊>Allergy >The effects of selected probiotic strains on the development of eczema (the PandA study).
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The effects of selected probiotic strains on the development of eczema (the PandA study).

机译：所选益生菌菌株对湿疹发展的影响（PandA研究）。

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BACKGROUND: Modification of the intestinal microbiota by administration of probiotic bacteria may be a potential approach to prevent allergic disease. We aimed to study primary prevention of allergic disease in high-risk children by pre- and postnatal supplementation of selected probiotic bacteria. METHODS: In a double-blind, randomized, placebo-controlled trial, a mixture of probiotic bacteria selected by in-vitro experiments (Bifidobacterium bifidum, Bifidobacterium lactis, and Lactococcus lactis; Ecologic Panda) was prenatally administered to mothers of high-risk children (i.e. positive family history of allergic disease) and to their offspring for the first 12 months of life. RESULTS: Parental-reported eczema during the first 3 months of life was significantly lower in the intervention group compared with placebo, 6/50 vs 15/52 (P = 0.035). After 3 months, the incidence of eczema was similar in both groups. Cumulative incidence of parental-reported eczema at 1 and 2 years was 23/50 (intervention) vs 31/48 (placebo) and 27 (intervention) vs 34 (placebo), respectively. The number needed to treat was 5.9 at age 3 and 12 months and 6.7 at age 2 years. The intervention group was significantly more frequently colonized with higher numbers of Lc. lactis. Furthermore, at age 3 months, in vitro production of IL-5 (146 pg/ml vs 72 pg/ml; P = 0.04) was decreased in the probiotic-group compared with the placebo-group. CONCLUSIONS: This particular combination of probiotic bacteria shows a preventive effect on the incidence of eczema in high-risk children, which seems to be sustained during the first 2 years of life. In addition to previous studies, the preventive effect appears to be established within the first 3 months of life.
机译：背景：通过施用益生菌来改变肠道菌群可能是预防过敏性疾病的潜在方法。我们的目的是通过在产前和产后补充精选的益生菌来研究高危儿童的过敏性疾病的一级预防。方法：在一项双盲，随机，安慰剂对照试验中，向高危儿童的母亲产前服用了一种通过体外实验选择的益生菌混合物（双歧双歧杆菌，乳酸双歧杆菌和乳酸乳球菌;生态熊猫）。 （即过敏性疾病的阳性家族史）及其后12个月的后代。结果：与安慰剂相比，干预组出生后头三个月父母报告的湿疹明显低于安慰剂，分别为6/50和15/52（P = 0.035）。 3个月后，两组的湿疹发生率相似。父母报告的湿疹在1年和2年时的累积发生率分别为23/50（干预）对31/48（安慰剂）和27（干预）对34（安慰剂）。需要治疗的人数在3岁和12个月时为5.9，在2岁时为6.7。干预组的Lc数量明显增加。乳酸菌。此外，与安慰剂组相比，益生菌组在3个月大时，IL-5的体外产生量（146 pg / ml对72 pg / ml; P = 0.04）降低。结论：这种特殊的益生菌组合对高危儿童的湿疹发生率具有预防作用，这种作用在生命的头2年中似乎可以持续。除先前的研究外，预防作用似乎已在生命的头三个月内确立。

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