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首页> 外文期刊>Allergy >Increased expression of lipoxygenase enzymes during pollen season in nasal biopsies of pollen-allergic patients.
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Increased expression of lipoxygenase enzymes during pollen season in nasal biopsies of pollen-allergic patients.

机译：在花粉过敏患者的鼻活检中，在花粉季节中脂氧合酶的表达增加。

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Background: Exposure of patients sensitized to pollen triggers development of seasonal allergic rhinitis symptoms (SAR). Eicosanoids are a group of arachidonic acid metabolites contributing to the symptoms of SAR. The aim of this study was to investigate seasonal changes in the expression of enzymes of the eicosanoid pathway in the nasal mucosa of patients with SAR. Methods: Twenty SAR patients allergic to birch or grass and eight healthy subjects were included in the study. Patients registered rhinoconjunctivitis symptoms and use of rescue medication before and during the pollen season. Nasal biopsies were obtained before and around the peak of the season, sectioned and stained using markers for eosinophils, mast cells, T cells and neutrophils. Antibodies against the following enzymes were also used: cyclo-oxygenase (COX-1, COX-2), 5-lipoxygenase (5-LO), 5-lipoxygenase-activating factor (FLAP), LTA(4) hydrolase (LTA(4)h) and LTC(4) synthase (LTC(4)s). Results: During the pollen season symptoms of rhinoconjunctivitis and medication score increased significantly (P = 0.001; P = 0.001 respectively). During the pollen season numbers of eosinophils (P = 0.02) and cell positive 5-LO (P 0.02), LTC(4)s (P significantly. During season number of mast cells and cells expressing 5-LO and LTA(4)h were higher in SAR than in healthy controls group (P = 0.02; P = 0.01; P = 0.03 respectively). Conclusion: In sensitized patients exposure to pollen allergen results in increased expression of enzymes of the eicosanoid pathway.
机译：背景：对花粉敏感的患者接触会触发季节性变应性鼻炎症状（SAR）的发展。类花生酸是导致SAR症状的一组花生四烯酸代谢产物。这项研究的目的是调查SAR患者鼻黏膜中类花生酸途径酶的表达的季节性变化。方法：本研究包括20名对桦树或草过敏的SAR患者和8名健康受试者。在花粉季节之前和期间，患者会出现鼻结膜炎的症状并使用急救药物。在季节高峰之前和前后进行鼻活检，切片并使用嗜酸性粒细胞，肥大细胞，T细胞和嗜中性粒细胞的标记进行染色。还使用了针对以下酶的抗体：环加氧酶（COX-1，COX-2），5-脂氧合酶（5-LO），5-脂氧合酶激活因子（FLAP），LTA（4）水解酶（LTA（4） ）h）和LTC（4）合酶（LTC（4）s）。结果：在花粉季节，鼻结膜炎的症状和用药得分显着增加（分别为P = 0.001; P = 0.001）。在花粉季节，嗜酸性粒细胞（P = 0.02）和细胞阳性的5-LO（P 0.02），LTC（4）s（P显着。在肥大细胞和表达5-LO和LTA（4）h的细胞的季节数结论：在致敏的患者中，花粉过敏原暴露导致类花生酸途径酶的表达增加，SAR值高于健康对照组（分别为P = 0.02; P = 0.01; P = 0.03）。

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