Short-term prophylactic treatment of hereditary angioedema with icatibant.

Marques L; Domingo D; Maravall F

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Short-term prophylactic treatment of hereditary angioedema with icatibant.

机译：依卡替班短期预防性治疗遗传性血管性水肿。

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Hereditary type 1 angioedema (HAE) due to quantitative deficiency of Cl-esterase inhibitor (Cl-INH) is a bradykinin- dependent dis- ease that can be treated with icatibant (Jerini, Berlin), a novel bradykinin B2-receptor antagonist (1). Patients with HAE can suffer bouts of angioedema with surgical or invasive medical procedures. In such cases a short-prophylactic treatment has to be considered (2, 3). There is no approved medication for this indication in Spain. Until now, patients in this situation were treated with intravenously administered Cl-INH concentrate derived from human plasma.

机译：由于Cl酯酶抑制剂（Cl-INH）的定量缺乏而导致的遗传性1型血管性水肿（HAE）是一种缓激肽依赖性疾病，可以用新型缓激肽B2受体拮抗剂icatibant（Jerini，Berlin）治疗（1 ）。 HAE患者可通过外科或侵入性医疗程序患上血管性水肿。在这种情况下，必须考虑采取短期预防措施（2、3）。西班牙目前没有批准的药物可用于这种适应症。到目前为止，这种情况下的患者都接受了静脉注射源自人血浆的Cl-INH浓缩物的治疗。

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《Allergy》 |2010年第1期|共2页
作者
Marques L; Domingo D; Maravall F;
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正文语种 eng
中图分类医学免疫学;
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1. Short-term prophylactic treatment of hereditary angioedema with icatibant. [J] . Marques L, Domingo D, Maravall F Allergy . 2010,第1期

机译：依卡替班短期预防性治疗遗传性血管性水肿。
2. Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies [J] . Busse Paula J., Farkas Henriette, Banerji Aleena, BioDrugs: Clinical immunotherapeutics, biopharmaceuticals, and gene therapy . 2019,第1期

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3. Update on the Use of C1-Esterase Inhibitor Replacement Therapy in the Acute and Prophylactic Treatment of Hereditary Angioedema [J] . Li H. Henry, Riedl Marc, Kashkin Jay Clinical reviews in allergy & immunology. . 2019,第2期

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4. Helminths in the Treatment of Hereditary Angioedema: A Theoretical Model in Support of a Novel Therapeutic Option [C] . Donna L. Beales International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics . 2010

机译：蠕虫治疗遗传性血统血统：一种基于新型治疗选择的理论模型
5. Screening of natural products for their effect on kallikrein-kinin system: Potential implications in the treatment of hereditary angioedema. [D] . Madkhali, Hassan Abdu. 2015

机译：筛选天然产物对激肽释放酶激肽系统的影响：遗传性血管性水肿治疗的潜在影响。
6. Urticaria and Angioedema: 163 The Efficacy of Human Plasma-Derived C1-Inhibitor Concentrate Used for Prophylactic Treatment in Patients With Hereditary Angioedema Due to C1-Inhibitor Deficiency [O] . Dorottya Csuka, Zsuzsanna Zotter, Erika Szabó, 2012

机译：荨麻疹和血管性水肿：163人类血浆衍生的C1抑制剂浓缩物用于C1抑制剂缺乏导致的遗传性血管性水肿的预防性治疗
7. Short-term prophylactic use of C1-inhibitor concentrate in hereditary angioedema Findings from an international patient registry [O] . Magerl Markus, Frank Michael, Lumry William, 2017

机译：短期预防性使用C1抑制剂在遗传性血管性水肿中的预防作用

Short-term prophylactic treatment of hereditary angioedema with icatibant.

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