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首页> 外文期刊>Allergy >Maculopapular eruption to rivastigmine's transdermal patch application and successful oral desensitization.
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Maculopapular eruption to rivastigmine's transdermal patch application and successful oral desensitization.

机译:黄斑皮疹喷施卡巴拉汀的透皮贴剂和成功的口服脱敏。

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摘要

Rivastigmine is a reversible and non-competitive acetylcholinesterase and butyrylcholinesterase inhibitor used for the treatment of mild to moderate dementia of the Alzheimer's type and dementia because of Parkinson's disease (1). Rivastigmine has been available in capsule and liquid formulations since 1997, and in 2007 became available also in transdermal patch (2). Common adverse reactions to rivastigmine such as nausea, vomiting, diarrhea are transient and typically mild (3). Although transdermal patches are widely used, for their advantages over the conventional delivery methods (3), this is the first well-documented case of a delayed type hypersensitivity reaction to rivastigmine patch application in the form of an erythematous maculopapular eruption.
机译:Rivastigmine是一种可逆且非竞争性的乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂,用于治疗帕金森氏病引起的轻度至中度阿尔茨海默氏型痴呆和痴呆症(1)。自1997年以来,利伐斯明(Rivastigmine)可以胶囊和液体制剂的形式获得,2007年也以透皮贴剂形式获得(2)。对卡巴拉汀的常见不良反应例如恶心,呕吐,腹泻是短暂的,通常是轻度的(3)。尽管透皮贴剂已被广泛使用,但由于其优于常规递送方法的优势(3),这是对卡巴拉汀贴剂以红斑性黄斑疹的形式出现的迟发型超敏反应的第一个有据可查的案例。

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