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首页> 外文期刊>Allergy >IgG4 antibodies against rodents in laboratory animal workers do not protect against allergic sensitization.
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IgG4 antibodies against rodents in laboratory animal workers do not protect against allergic sensitization.

机译：实验室动物工作者中针对啮齿动物的IgG4抗体不能防止变态反应。

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BACKGROUND: The modified Th2 response, defined as an IgG4 response in the absence of IgE, is suggested to protect against the development of allergic sensitization. However, studies suggesting this protective effect all had a cross-sectional design, making it impossible to study the development of both responses. AIM OF THE STUDY: We aimed to study the dynamics in IgG4 antibodies in relation to allergic sensitization in an occupational cohort of starting laboratory animal workers. Moreover, we studied the relation between exposure, antibody responses, atopy and self reported allergic symptoms. METHODS: A total of 110 starting animal workers were followed for 2 years. IgG4 antibodies against rats and mice were assessed. Workers were tested for allergic sensitization and exposure to animal allergens was estimated. Symptom status was assessed using questionnaires. RESULTS: Rat and mouse specific IgG4 antibodies were present before the development of allergy and did not significantly change over time. Allergic sensitization was related to exposure and atopic status but high levels of IgG4 showed no protective effect. In contrary, workers that developed mouse specific sensitization during follow up had higher levels of mouse specific IgG4. Symptoms were related to allergic sensitization and IgG4 levels did not influence that relationship. CONCLUSIONS: IgG4 antibodies are present before IgE antibodies develop and IgG4 levels are stable over time. In our occupational cohort, the modified Th2 response had no protective effect on development of sensitization or allergic symptoms.
机译：背景：建议将修饰的Th2应答定义为在不存在IgE的情况下的IgG4应答，以防止发生过敏性致敏。但是，研究表明这种保护作用均具有横断面设计，因此无法研究两种反应的发生。研究的目的：我们的目的是在一个实验动物实验工人的职业队列中研究与过敏性致敏有关的IgG4抗体的动力学。此外，我们研究了暴露，抗体反应，特应性反应和自我报告的过敏症状之间的关系。方法：总共110名起始动物工作者被追踪了2年。评估了针对大鼠和小鼠的IgG4抗体。对工人进行了过敏敏化测试，并估计了他们对动物过敏原的接触。使用问卷调查评估症状状态。结果：大鼠和小鼠特异性IgG4抗体在变态反应发生之前就已存在，并且不会随时间而显着变化。过敏性致敏与暴露和特应性状态有关，但高水平的IgG4没有保护作用。相反，在随访期间发生小鼠特异性致敏作用的工人的小鼠特异性IgG4水平较高。症状与过敏性致敏有关，IgG4水平不影响这种关系。结论：IgG4抗体在IgE抗体出现之前就已经存在，并且IgG4水平随时间稳定。在我们的职业队列中，改良的Th2反应对致敏或过敏症状的发展没有保护作用。

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