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首页> 外文期刊>Allergy >Comparable in vivo anti-inflammatory potency at trough using inhaled fluticasone furoate and propionate.
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Comparable in vivo anti-inflammatory potency at trough using inhaled fluticasone furoate and propionate.

机译：使用糠酸氟替卡松和丙酸酯吸入时在体内产生的可比拟的体内抗炎功效。

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Dear Sir,We read with interest the article of Van Den Berge et al. (1) which showed significant bronchoprotection against AMP (adenosine monophosphate) challenge at 14 and 24 h after a single 1000 mug dose of fluticasone furoate (FF), but only at 14 h after fluticasone propionate (FP). The authors suggest that FF may have a longer duration of action than FP, although they state that the study was not designed to compare the two drugs but only to analyse the difference against placebo. Interestingly for the intranasal formulation both drugs are indicated as a once daily formulation, but with FF being given at half the dose compared to FP. Since inhaled FP is recommended to be given twice daily with a 12 h dosing interval, while inhaled FF is given once daily with a 24 h interval, the more valid comparison at 26 h at trough would have been after a second dose of FP vs after a first dose of FF.
机译：尊敬的先生，我们感兴趣地阅读了Van Den Berge等的文章。 （1）在单剂量1000杯糠酸氟替卡松（FF）后14和24小时，但仅在丙酸氟替卡松（FP）之后14 h，对AMP（单磷酸腺苷）攻击显示出显着的支气管保护作用。作者认为FF可能比FP具有更长的作用持续时间，尽管他们指出这项研究并非旨在比较两种药物，而只是为了分析与安慰剂的差异。有趣的是，对于鼻内制剂，两种药物均被指示为每日一次制剂，但与FP相比，FF的剂量为一半。由于建议每天两次以12小时的给药间隔吸入FP，而每天两次以24 h的间隔吸入FF，因此在谷底26 h比较有效的比较是第二次FP与之后FF的第一剂。

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