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首页> 外文期刊>Allergy >Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice
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Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice

机译：PPARα（而非β/δ或γ）的局部应用可抑制NC / Nga小鼠的特应性皮炎

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Background: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which regulate not only adipogenesis and proliferation/ differentiation but also the immune response of cells. Because topical application of the activators of some PPAR isoforms improved clinical symptoms in patients with atopic dermatitis (AD), we investigated the role of PPAR activators using a murine AD model in NC/Nga mice; to the best of our knowledge, this has not been previously reported. Methods: Activators of three PPAR isoforms (α, β/δ, γ) were topically applied on inflamed skin in a murine AD model that was developed by repeated topical application of mite antigen in NC/Nga mice. The efficacy of each topical PPAR activator was evaluated immunologically and serologically. Results: Topical application of the PPARα activator, but not of the activators of PPARβ/δ or PPARγ, improved clinical dermatitis, reduced inflammatory cell infiltration in the dermis, and alleviated the elevation of serum IgE levels. In addition, PPARa expression was downregulated in the epidermis in our murine AD model, as is seen in patients with AD. Conclusions: Topical application of PPARα activator could be a potent therapeutic agent for patients with AD and could take the place of topical steroid treatments.
机译：背景：过氧化物酶体增殖物激活受体（PPAR）是核受体，不仅调节脂肪形成和增殖/分化，而且还调节细胞的免疫反应。由于局部应用某些PPAR异构体的激活剂可改善特应性皮炎（AD）患者的临床症状，因此我们使用鼠AD模型研究了NC / Nga小鼠中PPAR激活剂的作用。据我们所知，以前尚未有过报道。方法：在鼠AD模型中，将三种PPAR亚型（α，β/δ，γ）的激活剂局部应用于发炎的皮肤，该模型是通过在NC / Nga小鼠中反复局部应用螨抗原而开发的。通过免疫学和血清学评估了每种局部PPAR激活剂的功效。结果：局部应用PPARα激活剂，但不局部应用PPARβ/δ或PPARγ激活剂，改善临床皮炎，减少真皮中炎性细胞浸润，并减轻血清IgE水平升高。另外，正如在AD患者中所见，在我们的小鼠AD模型中，表皮中的PPARa表达被下调。结论：局部应用PPARα激活剂可能是AD患者的有效治疗药物，可代替局部类固醇治疗。

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