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Maternal testosterone in pregnancy and atopic outcomes in childhood.

机译：孕期孕妇睾丸激素和儿童期特应性结局。

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BACKGROUND: In mice, androgens downregulate Th2 cytokine responses, but whether androgen levels during pregnancy might influence the development of allergy in the offspring has not been studied. METHODS: In the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort of 14 541 pregnancies, we related maternal blood total testosterone during pregnancy, measured in a subset of the cohort, to allergic outcomes in the offspring, including asthma, hayfever, eczema (n=543) and wheezing (n=532) at 69-81 months, and atopy (positive skin prick test to Dermatophagoides pteronyssinus, cat or grass, n=386) and blood total immunoglobulin E (IgE; n=314) at 7 years. We used logistic and linear regression to analyse binary outcomes and log-transformed IgE, respectively, controlling for potential confounders. RESULTS: Maternal testosterone was negatively associated with total IgE in boys [adjusted geometric mean ratio (GMR), per doubling of testosterone, 0.33 (0.20-0.55), P=0.000038 (n=168)], but not in girls [GMR 1.04 (0.53-2.06), P=0.91 (n=146)], P-value interaction 0.0086. The effect in boys was even stronger in the absence of maternal atopic disease. Testosterone was not associated with skin test positivity or atopic disease in either sex. CONCLUSIONS: Higher testosterone levels in pregnancy are associated with lower IgE production in boys.
机译：背景：在小鼠中，雄激素会下调Th2细胞因子的反应，但尚未研究怀孕期间雄激素水平是否会影响后代过敏的发展。方法：在一项以人口为基础的14 541例妊娠出生队列的父母和子女的雅芳纵向研究（ALSPAC）中，我们将在该队列的一个子集中测量的孕期孕妇血液总睾丸激素与后代的过敏结果相关联，包括69-81个月的哮喘，花粉热，湿疹（n = 543）和喘息（n = 532），以及特应性（对Dermatophagoides pteronyssinus，猫或草的阳性皮肤点刺试验，n = 386）和血液总免疫球蛋白E（IgE ; n = 314），共7年。我们分别使用logistic和线性回归分析了二进制结果和对数转换后的IgE，以控制潜在的混杂因素。结果：男孩的睾丸激素与总IgE呈负相关[校正的几何平均比（GMR），每增加一倍的睾丸激素，为0.33（0.20-0.55），P = 0.000038（n = 168）]，而在女孩中则没有[GMR 1.04] （0.53-2.06），P = 0.91（n = 146）]，P值相互作用0.0086。在没有产妇特应性疾病的情况下，对男孩的作用甚至更强。男女中的睾丸激素均与皮肤测试阳性或特应性疾病无关。结论：妊娠期睾丸激素水平升高与男孩IgE生成量降低有关。

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