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首页> 外文期刊>Allergy >Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series.
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Ocular manifestations and complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: an Asian series.

机译：史蒂文斯-约翰逊综合征和中毒性表皮坏死溶解的眼部表现和并发症：亚洲丛书。

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摘要

BACKGROUND: To describe the acute and late ocular manifestations and complications in toxic epidermal necrosis (TEN) and Stevens-Johnson syndrome (SJS), and identify predictors for development of late complications. METHODS: Cases of TEN and SJS during a 9-year period were included. Patients with ocular involvement were reviewed for acute ocular complications. Patients with a minimum 6 months follow-up were reviewed for late complications. Records were reviewed for their demographics, etiology, and severity of ocular involvement. RESULTS: There were 117 patients with a mean age of 52.2 +/- 18.6 years. Eighty-one of these (69%) had acute ocular involvement. This was mild in 40%, moderate in 25% and severe in 4%. Adverse drug reactions were the predominant cause. Patients with thrombocytopenia had more severe acute ocular involvement. Forty-four patients had a minimum 6 months of follow-up and half developed late complications. Severe dry eyes and trichiatic lashes were the commonest late complications. Patients treated with topical antibiotic were more likely to have late complications, particularly dry eyes. There was no difference in the severity of acute eye involvement or late complications when SJS and TEN patients were compared. The severity of the acute ocular disease and abnormal laboratory tests were not found to be the significant risk factors of late complications. CONCLUSIONS: Ocular involvement is common in SJS and TEN and can be severe and blinding. The severity of acute ocular complications does not predict late complications. The diagnosis of TEN does not imply a more severe ocular involvement or increased frequency of late ocular complications compared with SJS. Care should be taken even in mild cases. Appropriate intervention during acute ocular disease may prevent late complications.
机译：背景：描述中毒性表皮坏死（TEN）和史蒂文斯-约翰逊综合征（SJS）的急性和晚期眼部表现和并发症，并确定晚期并发症发生的预测因素。方法：包括9年期间的TEN和SJS病例。对有眼部受累的患者进行了急性眼部并发症的检查。对至少随访6个月的患者进行了后期并发症的检查。对记录进行了人口统计学，病因学和眼部受累程度的审查。结果：117例患者的平均年龄为52.2 +/- 18.6岁。其中八十一（69％）人患有急性眼部受累。轻度为40％，中度为25％，重度为4％。药物不良反应是主要原因。血小板减少症患者的急性眼受累更为严重。 44名患者至少接受了6个月的随访，一半患者出现了晚期并发症。严重的干眼症和滴眼睫毛是最常见的晚期并发症。使用局部抗生素治疗的患者更容易出现后期并发症，尤其是干眼症。比较SJS和TEN患者时，急性眼部受累或晚期并发症的严重程度没有差异。未发现急性眼病的严重程度和实验室检查异常是晚期并发症的重要危险因素。结论：眼部受累在SJS和TEN中很常见，可能严重且致盲。急性眼部并发症的严重程度不能预测晚期并发症。与SJS相比，TEN的诊断并不意味着更严重的眼部受累或晚期眼部并发症的发生率增加。即使在轻度情况下也要小心。在急性眼疾病中进行适当干预可以预防晚期并发症。

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