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首页> 外文期刊>Allergy >Antibody blocking of MHC II on human activated regulatory T cells abrogates their suppressive potential.
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Antibody blocking of MHC II on human activated regulatory T cells abrogates their suppressive potential.

机译：对人激活的调节性T细胞的MHC II抗体阻断可消除其抑制潜力。

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摘要

Natural regulatory CD4(+)CD25(+)Foxp3(+) T cells control peripheral immune responses. Freshly isolated regulatory T-cell populations are regarded as being unable to suppress the proliferation of strongly stimulated effector T cells. We now provide evidence that it is not the strength of the proliferative signal to effector T cells but activation and accessibility of regulatory T cells that determine whether suppression may occur. Human regulatory T cells were initially cocultured with allogeneic monocyte-derived dendritic cells for a short time and were then rendered accessible for effector T cells by removal of the dendritic cells. That way activated regulatory T cells effectively suppressed the proliferation of autologous effector T cells which was strongly driven by cell-sized Dynabeads coated with CD3/CD28 antibodies. Although regulatory T cells are known to display MHC II molecules and to upregulate their expression along with activation, a role of MHC II molecules in forming the contact to effector T cells was not yet envisaged. However, blocking of MHC II on activated regulatory T cells abrogated their suppressive potential. It should not be excluded that self-MHC molecules on physically accessible activated regulatory T cells arrange the contact to effector T cells.
机译：自然调节性CD4（+）CD25（+）Foxp3（+）T细胞控制外周免疫反应。新鲜分离的调节性T细胞群被认为不能抑制强烈刺激的效应T细胞的增殖。我们现在提供证据，不是效应子T细胞的增殖信号的强度，而是调节性T细胞的激活和可及性决定是否可能发生抑制作用。首先将人类调节性T细胞与异体单核细胞衍生的树突状细胞共培养短时间，然后通过去除树突状细胞使效应T细胞可及。这样，活化的调节性T细胞可有效抑制自体效应T细胞的增殖，这是由涂有CD3 / CD28抗体的细胞大小的Dynabeads强烈驱动的。尽管已知调节性T细胞展示MHC II分子并与激活一起上调其表达，但尚未设想MHC II分子在形成与效应T细胞的接触中的作用。但是，在激活的调节性T细胞上阻断MHC II可以消除其抑制潜力。不应排除的是，物理可接近的活化调节性T细胞上的自身MHC分子可安排与效应T细胞的接触。

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