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首页> 外文期刊>Allergy >Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis.
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Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis.

机译：变应性鼻炎引起的鼻变应原刺激后鼻黏膜中神经营养因子和神经营养因子受体表达的调节。

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BACKGROUND: Patients with allergic rhinitis (AR) feature both allergic airway inflammation and a hyperresponsiveness to nonspecific stimuli which is partly neuronally controlled. Still, it is unclear whether or not neurotrophins are involved in airway pathophysiology of AR and in nasobronchial interaction. METHODS: Nine AR patients with mono-allergy to grass pollen and nine healthy controls underwent nasal allergen provocation (NP). Serum samples, nasal and bronchial biopsies were taken before (T(0)) and 24 h after (T(24)) NP. Pan-neurotrophin receptor p75(NTR), tyrosine kinase A (trkA), trkB, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) were assessed with immunohistochemistry, and NGF and BDNF levels with ELISA. RESULTS: At T(24), BDNF and NGF were upregulated in nasal mucosa (P < 0.05) and increased in the peripheral blood of AR compared with T(0). The increase in nasal BDNF expression correlated positively with the maximum increase in total nasal symptom score in AR (P = 0.02). p75(NTR) was expressed on peripheral nerves and epithelial layer, trkA on endothelial cells, and trkB on mast cells. trkB + mast cells significantly decreased after NP in AR (P < 0.01). NP did not modulate p75(NTR) and trkA expression in nasal mucosa and had no effect on the expression of neurotrophins and receptors in bronchial mucosa. CONCLUSION: This study shows that neurotrophins and their receptors are expressed in human airways. Allergic rhinitis was characterized by a modulation of BDNF, NGF, and trkB in nasal mucosa after NP and a correlation of nasal BDNF with the maximal increase of total nasal symptom score. Therefore, our data suggest that neurotrophins participate in upper-airway pathophysiology in AR, whereas their role in nasobronchial interaction remains unclear.
机译：背景：患有过敏性鼻炎（AR）的患者既具有过敏性气道炎症，又具有对部分神经元控制的非特异性刺激的过度反应。尚不清楚神经营养蛋白是否参与AR的气道病理生理和鼻支气管相互作用。方法：9例对草花粉单过敏的AR患者和9例健康对照者接受了鼻过敏原激发（NP）。在（T（0））之前和（T（24））NP后24小时采集血清样本，鼻腔和支气管活检样本。泛神经营养蛋白受体p75（NTR），酪氨酸激酶A（trkA），trkB，神经生长因子（NGF）和脑源性神经营养因子（BDNF）进行了免疫组织化学评估，而NGF和BDNF水平则通过ELISA进行了评估。结果：在T（24）时，与T（0）相比，鼻粘膜中BDNF和NGF的表达上调（P <0.05），而AR外周血中BDNF和NGF的表达增加。鼻腔BDNF表达的增加与AR总鼻症状评分的最大增加呈正相关（P = 0.02）。 p75（NTR）在周围神经和上皮层表达，trkA在内皮细胞上表达，trkB在肥大细胞上表达。 NP后AR患者trkB +肥大细胞显着减少（P <0.01）。 NP不会调节鼻黏膜中p75（NTR）和trkA的表达，并且对支气管黏膜中神经营养因子和受体的表达没有影响。结论：这项研究表明神经营养蛋白及其受体在人的气道中表达。过敏性鼻炎的特征是NP后鼻黏膜中BDNF，NGF和trkB的调节以及鼻BDNF与总鼻症状评分最大增加的相关性。因此，我们的数据表明神经营养蛋白参与AR的上呼吸道病理生理学，而它们在鼻支气管相互作用中的作用仍不清楚。

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