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首页> 外文期刊>Allergy >GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids
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GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids

机译：GLCCI1变异体加速了接受吸入糖皮质激素治疗的哮喘患者的肺功能衰退

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Background: In steroid-naive patients with asthma, several gene variants are associated with a short-term response to inhaled corticosteroid (ICS) treatment; this has mostly been observed in Caucasians. However, not many studies have been conducted for other ethnicities. Here, we aimed to determine the relationship between the annual decline in forced expiratory flow volume in one second (FEV1) and the variant of the glucocorticoid-induced transcript 1 gene (GLCCI1) in Japanese patients with asthma receiving long-term ICS treatment, taking into account the effect of high serum periostin levels, a known association factor of pulmonary function decline and a marker of refractory eosinophilic/Th2 inflammation. Methods: In this study, 224 patients with asthma receiving ICS treatment for at least 4 years were enrolled. The effects of single-nucleotide polymorphisms (SNPs) in GLCCI1, stress-induced phosphoprotein 1 (STIP1), and T gene on the decline in FEV1 of 30 ml/year or greater were determined. Results Besides the known contributing factors, that is, the most intensive treatment step, ex-smoking, and high serum periostin levels (≥95 ng/ml), the GG genotype of GLCCI1 rs37973, and not other SNPs, was independently associated with a decline in FEV1 of 30 ml/year or greater. When patients were stratified according to their serum periostin levels, the GG genotype of rs37973 was significantly associated with blood eosinophilia (≥250/μl) in the high serum periostin group. Conclusions: A GLCCI1 variant is a risk factor of pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment. Thus, GLCCI1 may be associated with response to ICS across ethnicities.
机译：背景：在未接受类固醇治疗的哮喘患者中，几种基因变异与吸入皮质类固醇（ICS）治疗的短期反应有关;这在白种人中最常见。但是，针对其他种族的研究很少。在这里，我们的目的是确定接受长期ICS治疗的日本哮喘患者，一秒钟的强制呼气流量年度下降（FEV1）与糖皮质激素诱导的转录本1基因（GLCCI1）变异之间的关系。考虑到高血清骨膜素水平的影响，已知的肺功能下降的相关因素和难治性嗜酸性/ Th2炎症的标志物。方法：本研究纳入了接受ICS治疗至少4年的224例哮喘患者。确定了GLCCI1，应激诱导的磷蛋白1（STIP1）和T基因中单核苷酸多态性（SNP）对FEV1下降30 ml /年或更高的影响。结果除了已知的致病因素，即最密集的治疗步骤，抽烟和高血清骨膜素水平（≥95ng / ml）外，GLCCI1 rs37973的GG基因型与其他SNP独立相关。 FEV1下降30毫升/年或更高。当根据血清骨膜素水平对患者进行分层时，高血清骨膜素组中rs37973的GG基因型与血液嗜酸性粒细胞增多（≥250/μl）显着相关。结论：在接受长期ICS治疗的日本哮喘患者中，GLCCI1变异是肺功能下降的危险因素。因此，GLCCI1可能与跨种族对ICS的响应相关。

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