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首页> 外文期刊>Allergy >Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption.
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Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption.

机译：淋巴细胞转化试验在诊断药物敏感性中的效用：取决于其时机和药物萌发的类型。

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BACKGROUND: Lymphocyte transformation test (LTT) is a safety and reproducible test to assess activation of drug-specific T cells in vitro; however, there are several practical concerns such as the time of testing and the influence of treatment. Our aim was to define the right timing to perform LTT for determining the causative agent in various types of drug reactions. METHODS: Lymphocyte transformation test was performed at different time points during the evolution of three types of drug reactions, maculo-papular type of drug eruptions (MP), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and drug-induced hypersensitivity syndrome/drug rash and eosinophilia with systemic symptoms (DIHS/DRESS). RESULTS: Positive LTT reactions were obtained when the test was performed at the acute stage but not the recovery stage in MP and SJS/TEN, while positive LTT reactions were obtained at the recovery stage but not the acute stage in DIHS/DRESS, regardless of treatment with systemic prednisolone. CONCLUSIONS: Lymphocyte transformation test is a reliable method to define the causative agent, when LTT is performed at the right timing depending on the type of drug reactions. Lymphocyte transformation test should be performed within 1 week after the onset of skin rashes in patients with MP and SJS/TEN; and 5-8 weeks after in patients with DIHS/DRESS, respectively.
机译：背景：淋巴细胞转化试验（LTT）是一种安全且可重复的试验，用于评估体外药物特异性T细胞的激活。但是，存在一些实际问题，例如测试时间和治疗的影响。我们的目的是确定执行LTT的正确时机，以确定各种类型药物反应中的病原体。方法：在三种类型的药物反应的演变过程中，在不同时间点进行淋巴细胞转化试验，这是黄斑丘疹型药物爆发（MP），史蒂文斯-约翰逊综合征/中毒性表皮坏死溶解（SJS / TEN）和药物诱导的超敏综合征/皮疹和嗜酸性粒细胞增多症伴全身症状（DIHS / DRESS）。结果：MP和SJS / TEN在急性期进行测试时获得了LTT阳性反应，而在DIHS / DRESS中，在恢复期却获得了LTT阳性反应，而在急性期却未获得急性表达，无论全身泼尼松龙治疗。结论：根据药物反应的类型，在正确的时间进行LTT时，淋巴细胞转化试验是确定病原体的可靠方法。 MP和SJS / TEN患者皮疹发作后1周内应进行淋巴细胞转化试验; DIHS / DRESS患者分别在术后5周和5-8周。

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