Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

Dodev T. S.; Bowen H.; Shamji M. H.; Bax H. J.; Beavil A. J.; McDonnell J. M.; Durham S. R.; Sutton B. J.; Gould H. J.; James L. K.

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Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

机译：特异性相同但类别不同的抗体对变应原依赖性IgE活性的抑制

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IgG(4) purified from patients undergoing specific allergen immunotherapy inhibits the activities of the serum IgE in in vitro assays and is thought to reduce the symptoms of the disease. However, it is not known whether this is related to an intrinsic property of this subclass or only the allergen specificity. We tested the hypothesis that allergen specificity is the critical determinant for this activity using a panel of antibodies with identical specificity but different subclasses. The different antibodies were all able to inhibit the activity of IgE to the same extent. We demonstrate that specificity is the dominant factor determining the ability of an antibody to block allergen-dependent IgE activity.

机译：从接受特定过敏原免疫治疗的患者中纯化的IgG（4）在体外测定中抑制血清IgE的活性，并被认为可以减轻疾病的症状。但是，尚不知道这是否与该亚类的固有特性有关，还是仅与过敏原特异性有关。我们使用一组具有相同特异性但不同亚类的抗体测试了以下假设：过敏原特异性是该活性的关键决定因素。不同的抗体都能够在相同程度上抑制IgE的活性。我们证明特异性是决定抗体阻断变应原依赖性IgE活性的能力的主要因素。

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《Allergy》 |2015年第6期|共5页
作者
Dodev T. S.; Bowen H.; Shamji M. H.; Bax H. J.; Beavil A. J.; McDonnell J. M.; Durham S. R.; Sutton B. J.; Gould H. J.; James L. K.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
allergen; antibody; immunotherapy; isotype; specificity;

机译：过敏原;抗体;免疫疗法;同种型;特异性;

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专利

1. Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class [J] . Dodev T. S., Bowen H., Shamji M. H., Allergy . 2015,第6期

机译：特异性相同但类别不同的抗体对变应原依赖性IgE活性的抑制
2. Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity [J] . Aliaksei Shymanets, Prajwal, Oscar Vadas, The biochemical journal . 2015,第1期

机译：单克隆抗体对Gβγ刺激的IB类磷酸肌醇3-激酶（PI3K）变体的不同抑制作用。 p101作为PI3Kγ酶活性的Gβγ依赖调节剂的特定功能
3. Different inhibition of G beta gamma-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a G beta gamma-dependent regulator of PI3K gamma enzymatic activity [J] . Shymanets Aliaksei, Prajwal, Vadas Oscar, The Biochemical Journal . 2015,第Pta1期

机译：单克隆抗体对Gβγ刺激的IB类磷酸肌醇3激酶（PI3K）变异体的不同抑制作用。 p101作为PI3K伽马酶活性的Gβ伽马依赖性调节剂的特定功能
4. Probability of Hospital Admission with Acute Asthma Exacerbation Increases with Increasing Specific IgE Antibody Levels [C] . C.S. Murray, C. Poletti, S. Ahlstedt, Collegium Internationale Allergologicum . 2007

机译：急性哮喘加剧的医院入院概率随着特定的IgE抗体水平的增加而增加
5. A novel approach to control and regulate the classical complement pathway: Highly specific inhibition of C1q globular head binding to human IgG using an engineered single chain antibody variable fragment; recruiting C1q to HER2 /neu positive cells using truncated bispecific antibodies [D] . Hwang, Hee Young 2007

机译：一种控制和调节经典补体途径的新方法：使用工程化的单链抗体可变片段高度特异性地抑制C1q球头与人IgG的结合；使用截短的双特异性抗体将C1q募集到HER2 / neu阳性细胞
6. Inhibition of allergen‐dependent IgE activity by antibodies of the same specificity but different class [O] . T. S. Dodev, H. Bowen, M. H. Shamji, -1

机译：特异性相同但类别不同的抗体抑制变应原依赖性IgE活性
7. Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class [O] . Dodev, T. S., Bowen, H., Shamji, M. H., 2015

机译：特异性相同但类别不同的抗体对变应原依赖性IgE活性的抑制

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

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