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首页> 外文期刊>ACS applied materials & interfaces >Synthesis of Magnetic Molecularly Imprinted Poly(ethylene-co-vinyl alcohol) Nanoparticles and Their Uses in the Extraction and Sensing of Target Molecules in Urine
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Synthesis of Magnetic Molecularly Imprinted Poly(ethylene-co-vinyl alcohol) Nanoparticles and Their Uses in the Extraction and Sensing of Target Molecules in Urine

机译：磁性分子印迹聚乙烯亚乙烯醇纳米粒子的合成及其在尿中目标分子的提取和传感中的应用

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Superparamagnetic nanoparticles are of great current interest for biomedical applications in both diagnostics and treatment. Magnetic nanoparticles (MNP) can be manipulated by magnetic fields, so that when functionalized. they can be used for the purification and separation of biomolecules and even whole cells. Here we report combining the separation capabilities of MNPs with the functional (binding) capability of molecularly imprinted polymers. Albumin- creatinine-, lysozyme-. and urea-imprinted polymer nanoparticles were synthesized from poly{ethylene-co-ethylene alcohol) via phase inversion, with both target molecules and hydrophobic magnetic nanoparticles mixed within the polymer solution Several ethylene:ethylene alcohol mole ratios were studied The rebinding capacities for those three target molecules varied from 0,76 ± 0.02 to 5.97 ± 0.04 mg/g of molecularly Imprinted magnetic nanoparticles. Lastly, the composite nanoparticles were used for separation and sensing of template molecules (e.g.. human serum albumin) in real samples (urine) and results were compared with a commercial ARCHITECT ci 8200 system.
机译：目前，超顺磁性纳米粒子在生物医学领域的诊断和治疗领域都引起了人们的极大兴趣。磁性纳米粒子（MNP）可以被磁场操纵，因此在功能化时可以使用。它们可用于纯化和分离生物分子，甚至整个细胞。在这里，我们报告结合MNPs的分离能力与分子印迹聚合物的功能（结合）能力。白蛋白-肌酐-，溶菌酶-。并通过相转化法从聚（乙烯-共-乙烯醇）合成尿素印迹的聚合物纳米粒子，目标分子和疏水性磁性纳米粒子均混入聚合物溶液中，研究了几种乙烯：乙烯摩尔比。目标分子的分子印迹磁性纳米粒子的浓度范围为0.76±0.02至5.97±0.04 mg / g。最后，将复合纳米颗粒用于分离和检测实际样品（尿液）中的模板分子（例如人血清白蛋白），并将结果与​​商用ARCHITECT ci 8200系统进行比较。

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