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Clinical utility of in situ hybridization for diagnosing respiratory tract infection and sepsis

机译：原位杂交诊断呼吸道感染与脓毒症的临床效用

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摘要

We studied the clinical utility of in situ hybridization (Hybrisep) in diagnosing respiratory infection and/ or sepsis. Peripheral blood was taken from patients with respiratory infections and suspected sepsis for both routine blood culture and in situ hybridization, and focal samples including sputum, bronchoalveolar lavage, and central and thoracic catheter, were simultaneously examined for bacterial culture. Specimens numbered 46. The clinical diagnosis was 20 cases of septicemia, with 26 specimens diagnosed as respiratory infectious diseases including hospital-acquired pneumonia and pleurisy. Positive cases of in situ hybridization were seen in 19 specimens (41.3%) in all specimens, significantly higher than that in blood culture (17.4%). Respiratory infection showed a high positive rate in in situ hybridization. Interestingly, the bacterial pathogen detected by in situ hybridization was not always consistent with that taken from focal samples. Whether the pathogen isolated by in situ hybridizationis accurate etiologically or diagnostically remains unknown, but our findings suggest a polymicrobial infection in patients with hospital-acquired respiratory infections. In situ hybridization thus provides important information on the etiological pathogen in different infectious diseases.
机译：我们研究了原位杂交（Hybrisep）在诊断呼吸道感染和/或败血症中的临床效用。外周血从患有呼吸道感染患者和疑似败血症的患者进行常规血液培养，并且原位杂交，并且同时检查包括痰，支气管血管灌洗和中央和胸部导管的局灶性样品进行细菌培养。标本编号为46.临床诊断为20例败血症，患有26个标本作为呼吸道传染病，包括医院收养的肺炎和胸膜炎。在所有标本中，在19个标本（41.3％）中看到了原位杂交的阳性病例，显着高于血液培养物（17.4％）。呼吸道感染在原位杂交中显示出高阳性率。有趣的是，通过原位杂交检测的细菌病原体并不总是与局灶性样品取得的一致。通过原位杂交分离的病原体是否准确或诊断上仍然是未知的，但我们的研究结果表明医院呼吸道感染患者的多发性感染。因此，原位杂交提供了关于不同传染病的病因病原体的重要信息。

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