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Studies of treatment for Haemophilus influenzae type b meningitis in children

机译：儿童嗜血杆菌血液化脑膜炎的治疗研究

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摘要

We summarize 41 cases of bacterial meningitis in the last 11 years caused by Haemophilus influenzae. All isolates were serotype b strain (Hib). Initial chemotherapy was started with ceftriaxone (CTRX) in 22 cases, ampicillin plus cefotaxime (CTX) in 9, CTRX plus panipenem/betamipron in 5, and CTX in 2. Some 31 cases were treated mainly with CTRX. Although therapeutic antibiotics showed good susceptibility for isolates, 8 complicated cases (19.5%) occurred. Sequalae were observed in 7 (17.1%) but none were fatal. Five strains with elevated MIC of CTX (0.12 to 1 microg/mL) recovered after 2001, and 3 of 5 strains also showed elevated MIC of CTRX (0.12 to 0.5 microg/mL), but all were cured completely with CTRX. At present, no treatment failures due to antibiotic resistance have been observed, and CTRX remains suitable as initial therapy for Hib meningitis. A decline in susceptibility for third-generation cephalosporin against beta-lactamase-nonproducing ampicillin-resistant H. influenzae is emerging, however, so it will be necessary to consider combination therapy with CTRX given the foreseeable trend in MICs.
机译：我们在嗜血杆菌引起的后11年来总结了41例细菌脑膜炎。所有分离株均为血清型B株（HIB）。在22例中，氨苄青霉素（CTRX）开始初始化学疗法，在9，CTRX加上CTX中，在5中，CTX分别为21例。虽然治疗性抗生素显示出良好的分离株敏感性，但发生了8例（19.5％）。在7（17.1％）中观察到葡萄糖，但没有致命。在2001年后回收的CTX（0.12至1微孔/ mL）的升高的五种菌株，其中3个菌株中的3个也显示出CTRX的升高（0.12至0.5 microg / ml），但均用CTRX固化。目前，未观察到由于抗生素抗性导致的治疗失败，并且CTRX仍然适合作为血管脑炎的初始治疗。然而，第三代头孢菌素对β-内酰胺酶 - 无产氨苄青霉素H的易感性下降。然而，培养的流感均衡是培养麦克风中可预见的趋势所需的CTRX联合治疗。

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