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首页> 外文期刊>感染症学雑誌 >Anti-rabies antibody titers among subjects who received rabies post-exposure prophylaxis with foreign-made rabies vaccines at the beginning and followed with Japanese rabies vaccine
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Anti-rabies antibody titers among subjects who received rabies post-exposure prophylaxis with foreign-made rabies vaccines at the beginning and followed with Japanese rabies vaccine

机译：抗狂犬病抗体滴度，受试者接受狂犬病暴露的预防，在开始时与外国狂犬病疫苗接种，然后用日本狂犬病疫苗

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摘要

Recently travelers who were bitten by possibly rabid animals in rabies endemic regions and returned to Japan have increased in number. About half of them received rabies post-exposure prophylaxis (RPEP) with one or more doses of foreign-made rabies vaccines (FRV) in the local medical institutions. FRV, however, are not available in Japan so we have to continue the RPEP with Japanese rabies vaccine (JRV). It has not been demonstrated that an anti-rabies antibody induced with JRV following Vero cell rabies vaccine (PVRV) or chick embryo cell rabies vaccine (PCEC) could be high enough to prevent clinical rabies. We examined anti-rabies antibody (ARA) titers among the subjects visited our vaccine clinic to receive RPEP and obtained results as follows: the ARA titers after a total of 5 doses of PCEC or PVRV and JRV were high enough to prevent clinical rabies as after 5 doses of JRV. However, ARA titers obtained after receiving one dose of PVRV and 2 doses of JRV seemed lower than those produced after one dose of PCEC and 2 doses of JRV or 3 doses of JRV. To accelerate antibody production, consequently, the simultaneous intradermal and subcutaneous injection method of rabies vaccine may be applied to those who were bitten in their hands or head by possibly rabid animals and received only one dose of PVRV in rabies endemic regions.
机译：最近被狂犬病的狂犬病动物咬伤的旅行者，并返回日本的数量增加。其中大约有一半在当地医疗机构中接受了狂犬病暴露的预防预防预防（RPEP）（RPEP），在当地医疗机构中的一种或多种外来狂犬病疫苗（FRV）。然而，FRV在日本不可用，因此我们必须继续使用日本狂犬病疫苗（JRV）的RPEP。尚未证明使用JRV疫苗（PVRV）或鸡胚胚细胞狂犬病疫苗（PCEC）后用JRV诱导的抗狂犬病抗体可能高，以预防临床狂犬病。我们检查了受试者中的抗狂犬病抗体（ARA）滴度访问我们的疫苗诊所以获得RPEP并如下取得的结果：共有5剂PCEC或PVRV和JRV的ARA滴度足以防止临床狂犬病5剂的JRV。然而，在接受一剂PVRV和2剂JRV后获得的ARA滴度似乎低于一剂PCEC和2剂的JRV或3剂量JRV后产生的。为了加速抗体产生，因此，狂犬病疫苗的同时皮内和皮下注射方法可以应用于手中的人或通过狂犬病动物咬住的人，并仅在狂犬病流行区域中获得一剂PVRV。

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