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Usefulness of parenteral colistin in treating of lower respiratory infection due to multidrug-resistant Pseudomonas aeruginosa

机译:肠胃外肠球菌治疗多药抗性铜绿假单胞菌治疗较低呼吸道感染的用途

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We report a case of cystic fibrosis in a 19-year-old woman who suffered from frequent exacerbations of lower respiratory infection due to multidrug-resistant Pseudomonas aeruginosa and who was successfully treated with parenteral colistin. Multidrug-resistant Pseudomonas aeruginosa isolated from sputum had become resistant to all parenteral antibiotics commercially available in Japan. She did not show clinical improvement despite treatment with several different combinations of available antibiotics. We therefore obtained parenteral colistin from a pharmacy outside Japan. She responded well to parenteral colistin without apparent side effects such as serious nephrotoxicity or neurotoxicity. Colistin is therefore an important alternative antibiotic for treating multidrug-resistant Pseudomonas aeruginosa and its use should be considered in severe infection. We hope that parenteral colistin will become available in Japan in the near future.
机译:我们报告了一个19岁女性中囊性纤维化的病例,由于多药抗性假单胞菌铜绿假单胞菌和肠胃外胚胎成功治疗的呼吸道感染频繁加剧。 从痰中分离的多药抗性假单胞菌铜绿假单胞菌对日本市商购的所有肠胃外抗生素造成耐药。 尽管用几种不同的可用抗生素组合治疗,她没有表现出临床改善。 因此,我们从日本以外的药房中获得肠胃外科素。 她对肠胃外科素的反应很好,没有明显的副作用,例如严重的肾毒性或神经毒性。 因此,Colistin是治疗多药抗性铜绿假单胞菌的重要替代抗生素,其使用应在严重的感染中考虑。 我们希望肠胃外山药将在不久的将来在日本获得。

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