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首页> 外文期刊>ACS applied materials & interfaces >Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
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Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier

机译：使用聚乙二醇化氧化石墨烯作为纳米载体递送紫杉醇

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摘要

Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
机译：紫杉醇（PTX）是一种广泛使用的强效化疗药物。但是，水溶性低，生物利用度差以及患者出现耐药性限制了其生物学应用。在本报告中，我们提出了一种基于氧化石墨烯（GO）的新型癌症药物输送系统，氧化石墨烯是一种通过天然石墨的氧化获得的新型2D纳米材料，可提高PTX的利用率。首先将PTX与生物相容的6臂聚乙二醇连接，然后在温和的条件下通过简便的酰胺化过程将共价键引入GO片材表面，以提供药物递送系统GO-PEG-PTX（尺寸为50200 nm） 。以异硫氰酸荧光素为探针，倒置荧光显微镜证实，GO-PEG纳米载体可快速进入人肺癌A549和人乳腺癌MCF-7细胞。该纳米载体对A549和MCF-7细胞无毒，无需与PTX连接。然而，与游离PTX相比，GO-PEG-PTX在广泛的PTX浓度和时间范围内对A549和MCF-7细胞显示出显着的高细胞毒性。这种基于聚乙二醇化GO的纳米药物递送系统可能在生物医学中得到广泛应用。

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