...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels
【24h】

Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels

机译：间歇性变应性鼻炎不一致的单卵双胞胎的mRNA和蛋白质水平不同

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monozygotic (MZ) twins discordant for complex diseases may help to find disease mechanisms that are not due to genetic variants. Intermittent allergic rhinitis (IAR) is an optimal disease model because it occurs at defined time points each year, owing to known external antigens. We hypothesized that MZ twins discordant for IAR could help to find gene expression differences that are not dependent on genetic variants. We collected blood outside of the season from MZ twins discordant for IAR, challenged their peripheral blood mononuclear cells (PBMC) with pollen allergen in vitro, collected supernatants and isolated CD4+ T cells. We identified disease-relevant mRNAs and proteins that differed between the discordant MZ twins. By contrast, no differences in microRNA expression were found. Our results indicate that MZ twins discordant for IAR is an optimal model to identify disease mechanisms that are not due to genetic variants.
机译：对复杂疾病不满意的单卵（MZ）双胞胎可能有助于寻找并非遗传变异引起的疾病机制。间歇性变应性鼻炎（IAR）是一种最佳的疾病模型，因为由于已知的外部抗原，它每年在定义的时间点发生。我们假设与IAR不一致的MZ双胞胎可以帮助发现不依赖遗传变异的基因表达差异。我们在季节之外从与IAR不符的MZ双胞胎中收集血液，在体外用花粉过敏原攻击其外周血单核细胞（PBMC），收集上清液并分离CD4 + T细胞。我们鉴定出与疾病相关的mRNA和蛋白质在不一致的MZ双胞胎之间有所不同。相比之下，未发现microRNA表达的差异。我们的结果表明，与IAR不符的MZ双胞胎是识别非遗传变异的疾病机制的最佳模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号