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For t 2 DNA vaccine prevents Forcipomyia taiwana (biting midge) allergy in a mouse model

机译:对于t 2 DNA疫苗,可预防小鼠模型中的台湾灰熊(叮咬蚊)过敏

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Background: Forcipomyia taiwana (biting midge) is the most prevalent allergenic biting insect in Taiwan, and 60% of the exposed subjects develop allergic reactions. Subjects with insect allergy frequently limit their outdoor activities to avoid the annoyingly intense itchy allergic reactions, leading to significant worsening of their quality of life. Allergen-specific immunotherapy is the only known therapy that provides long-term host immune tolerance to the allergen, but is time-consuming and cumbersome. This study tested whether the For t 2 DNA vaccine can prevent allergic symptoms in For t 2-sensitized mice.
机译:背景:台湾灰飞虱(Forcipomyia taiwana,咬蚊)是台湾最流行的过敏性咬虫,60%的暴露对象会产生过敏反应。有昆虫过敏的受试者经常限制其户外活动,以避免烦人的剧烈的瘙痒过敏反应,从而导致其生活质量显着恶化。过敏原特异性免疫疗法是唯一已知的能对过敏原提供长期宿主免疫耐受的疗法,但既费时又麻烦。这项研究测试了For t 2 DNA疫苗是否可以预防For t 2致敏小鼠的过敏症状。

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