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首页> 外文期刊>日本輸血学会雑誌: Journal of the Japan Society of Blood Transfusion >血小板輸血後,B型肝炎を発症した再生不良性貧血症例の検討
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血小板輸血後,B型肝炎を発症した再生不良性貧血症例の検討

机译：血小板输血后对乙型肝炎的繁殖失败贫血检查。

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摘要

We report a patient with hepatitis B and aplastic anemia who was infected with donor hepatitis B virus during the so-called window period. A 22-year-old man was found to be anemic at age 7 and diagnosed as having aplastic anemia. He was given oxymetholon 25~50mg/day for 14 years (total 226 g). On August 3, 1995, a hepatic tumor developed as a complicated of anabolic steroid use. He had a liver biopsy on October 24, 1996. To prevent bleeding, he was received platelet concentrate (PC) transfusions at 20 units on October 23, 1996, 20 units on the 24, and 10 units on the 25. Histological findings suggested hepatic adenoma. Eleven weeks after PC transfusion,S-GPT became elevated, so donor's blood was tested at the Japanese Red Cross Central Blood Center.HBV-DNA was positive by the nested PCR method in retained donor blood. At 16 weeks after PC transfusion, the patient's laboratory data were as follows: HBsAg and HBcAb were positive,HBsAb was negative, S-GOT was 236 IU/L and S-GPT was 695 IU/ L.These values have since steadily improved, and bone marrow transplantation will be carried out after recovery.Recently, the incidence of post-transfusion hepatitis has decreased. Further reduction in risk will be obtained through the introduction of more sensitive screening tests,such as HBsAg (ElA) and PCR methods, and the registration of screened donors.
机译：我们在所谓的窗口期间报告患有乙型肝炎和脱位性贫血的患者和障碍性贫血。一个22岁的男子被发现在7岁时被贫血，并被诊断为具有增生性贫血。他给予氧别甲醇25〜50mg /天14岁（共226克）。 1995年8月3日，肝脏肿瘤作为一种合成代谢类固醇使用的复杂性。他于1996年10月24日患有肝脏活组织检查。为预防出血，他于1996年10月23日的20个单位接受了血小板浓缩物（PC）输血，20个单位，24个单位和10个单位。组织学结果提出了肝脏腺瘤。 PC输血11周后，S-GPT变得升高，因此供体血液在日本红十字中央血液中心测试。HBV-DNA通过保留的供体血液中的巢式PCR方法阳性。在PC输血后16周，患者的实验室数据如下：HBsAG和HBCAB是阳性的，HBsab是阴性的，S-GOT是236 IU / L和S-GPT是695 IU / L.这些价值从稳步提高，骨髓移植将在恢复后进行。即，输血后肝炎的发生率降低。通过引入更敏感的筛选试验，例如HBsAg（ELA）和PCR方法，以及筛选供体的登记，将获得风险的进一步降低。

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