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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >The Progression of Congestion Symptoms and Their Impacts A Naturalistic Study
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The Progression of Congestion Symptoms and Their Impacts A Naturalistic Study

机译：充血症状的进展及其影响自然研究

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Background: Morning nasal congestion due to allergic rhinitis (AR) has been shown to be one of the most consistent predictors of important patient-reported outcomes (PROs) including sleep symptoms and daytime functioning. This naturalistic study explores the progression of morning nasal symptoms and the relationships between morning nasal symptoms and PROs over time. Methods/Data base: This longitudinal 15-day study included 404 patients with confirmed AR. PRO measures administered at baseline, day 7, and day 15 included a daily diary of AR symptoms; Nocturnal Rhinitis Quality of Life Questionnaire; Mini-Rhinoconjuctivitis Quality of Life Questionnaire; Work Productivity and Activity Impairment; Positive and Negative Affect Schedule; and Medical Outcomes Study-Sleep Scale. Results: All congestion symptoms and PRO impacts of congestion decreased over the 2-week study period. Change in morning congestion symptoms was highly related to change in PRO subscales over the 2-week study period. Treatment and skin-test-confirmed AR vs. physician-confirmed AR were not significant predictors of change in congestion symptoms or PRO subscales. Patients with seasonal allergic rhinitis (SAR) had a reduction in morning congestion symptoms over the 2-week study period compared with patients with both SAR and perennial allergic rhinitis (PAR). Conclusions: The consistent and large correlations between the changes in morning congestion symptoms and PROs suggest that AR symptoms and their improvement or resolution corresponds with improvements in health-related quality of life (HRQL). Findings suggested that patients with SAR tended to have more symptom relief over the short study period compared to patients with both SAR and PAR.
机译：背景：变应性鼻炎（AR）引起的早晨鼻充血已被证明是重要的患者报告结局（PRO）的最一致的预测因子之一，PROs包括睡眠症状和白天的功能。这项自然主义的研究探讨了随着时间的流逝，早晨鼻部症状的发展以及早晨鼻部症状与PRO之间的关系。方法/数据库：这项为期15天的纵向研究包括404例确诊为AR的患者。在基线，第7天和第15天进行的PRO措施包括每日记录AR症状;夜间鼻炎生活质量问卷;迷你鼻结膜炎生活质量问卷;工作生产力和活动障碍;正面和负面影响表;和医学成果学习睡眠量表。结果：在2周的研究期内，所有的充血症状和充血的PRO影响均降低。在为期2周的研究期内，早晨充血症状的变化与PRO量表的变化高度相关。治疗和经皮肤测试确认的AR与经医生确认的AR并不是充血症状或PRO分量表变化的重要预测指标。与SAR和常年性变应性鼻炎（PAR）相比，季节性变应性鼻炎（SAR）的患者在2周的研究期间早晨充血症状有所减轻。结论：早晨充血症状和PRO的变化之间的一致性和较大的相关性表明，AR症状及其改善或缓解与健康相关生活质量（HRQL）的改善相对应。研究结果表明，与SAR和PAR病人相比，SAR病人在较短的研究期间内症状缓解率更高。

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