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首页> 外文期刊>American Journal of Physiology >Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis.
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Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis.

机译：热疗对青霉素诱导的急性胰腺炎中NF-κB结合活性的影响。

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摘要

Although the pancreatic heat shock response has already been reported to confer protective effects during experimental pancreatitis, the mechanism of action remains unknown. We investigated the effects of hyperthermia in cerulein-induced pancreatitis. Heat shock protein 70 (HSP70) expression in rats was induced by a 20-min period of water immersion (42 degrees C). The severity of pancreatitis as well as the pancreatic expression of cytokines, nuclear factor-kappaB (NF-kappaB), and inhibitory factor kappaB-alpha (IkappaB-alpha) were evaluated in the presence and absence of hyperthermia. We found that hyperthermia resulted in time-dependent expression of HSP70 within the pancreas associated with a reduction in the severity of acute pancreatitis. Tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression was significantly reduced in the presence of hyperthermia. Moreover, NF-kappaB activity was delayed in the presence of hyperthermia whereas IkappaB-alpha was stabilized in the cytoplasm.These results suggest that hyperthermia decreases the severity of cerulein-induced pancreatitis by decreasing cytokine expression in the pancreas through the modulation of NF-kappaB activity.
机译：尽管已经报道了胰腺热休克反应在实验性胰腺炎中具有保护作用，但其作用机理仍然未知。我们调查了热疗在青霉素诱导的胰腺炎中的作用。通过在水中浸泡20分钟（42摄氏度）来诱导大鼠热休克蛋白70（HSP70）的表达。在存在和不存在体温过高的情况下，评估胰腺炎的严重程度以及细胞因子，核因子-κB（NF-κB）和抑制因子κB-α（IkappaB-alpha）的胰腺表达。我们发现热疗导致胰腺内HSP70的时间依赖性表达，并伴有急性胰腺炎严重程度的降低。在存在高热的情况下，肿瘤坏死因子-α和细胞间粘附分子-1的表达显着降低。此外，在存在高热的情况下NF-κB的活性被延迟，而在细胞质中IkappaB-α被稳定了。活动。

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