• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations.
【24h】

Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations.

机译：运动引起的内皮功能障碍的改善不是由CV危险因素的变化所介导的：各种患者人群的汇总分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have pooled data from a series of our exercise training studies undertaken in groups with a broad range of vascular (dys) function to the examine the hypothesis that exercise-induced improvements in the conduit and/or resistance vessel function are related to improvements in risk factors for cardiovascular (CV) disease. Endothelium-dependent and -independent conduit vessel function were assessed by using wall tracking of high-resolution ultrasound images of the brachial artery response to flow-mediated dilation (FMD) and glyceryl trinitrate. Resistance vessel function was assessed using intrabrachial administration of acetylcholine (ACh), sodium nitroprusside, and NG-monomethyl-l-arginine. Randomized cross-over studies of 8-wk exercise training were undertaken in untreated hypercholesterolemic (n = 11), treated hypercholesterolemic (n = 11), coronary artery disease (n = 10), chronic heart failure (n = 12), Type 2 diabetic (n = 15), and healthy control subjects (n = 16). Exercise training did not significantly alter plasma lipids, blood pressure, blood glucose, waist-to-hip ratio, or body mass index values, despite significant improvement in both FMD and ACh responses. There were no correlations between changes in any risk factor variables and indexes of either resistance or conduit vessel function. We conclude that, in these subjects with antecedent vascular dysfunction, the beneficial effects of relatively short-term exercise training on vascular function are not solely mediated by the effects of exercise on CV risk factors.
机译：我们汇总了来自一系列具有广泛血管（功能障碍）功能的小组进行的一系列运动训练研究的数据，以检验以下假设：运动引起的导管和/或阻力血管功能改善与风险改善相关心血管（CV）疾病的因素。内皮依赖性和非依赖性导管血管功能通过使用对肱动脉对血流介导的扩张（FMD）和三硝酸甘油酯反应的高分辨率超声图像的壁跟踪来评估。使用肱内施用乙酰胆碱（ACh），硝普钠和NG-单甲基-1-精氨酸评估抗血管功能。在未经治疗的高胆固醇血症（n = 11），经治疗的高胆固醇血症（n = 11），冠状动脉疾病（n = 10），慢性心力衰竭（n = 12），2型患者中进行了8周运动训练的随机交叉研究糖尿病（n = 15）和健康对照组（n = 16）。尽管FMD和ACh反应均得到显着改善，但运动训练并没有显着改变血浆脂质，血压，血糖，腰臀比或体重指数值。任何危险因素变量的变化与阻力或导管功能的指数之间均无相关性。我们得出的结论是，在这些具有先前血管功能障碍的受试者中，相对短期的运动训练对血管功能的有益作用并不仅仅由运动对CV危险因素的影响来介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号