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首页> 外文期刊>American Journal of Physiology >Effects of daytime melatonin infusion in young adults.
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Effects of daytime melatonin infusion in young adults.

机译：白天褪黑激素对年轻人的影响。

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摘要

Daytime oral melatonin typically exerts soporific and thermoregulatory effects; however, it is not clear whether these effects reflect the normal physiological response to endogenous nocturnal melatonin production. We infused melatonin at doses that produced physiological and supraphysiological steady-state levels in 24 young adults during two daytime bed rest protocols. From 1000 to 1630, subjects were infused intravenously with saline or melatonin in counterbalanced order. Each group of eight subjects received melatonin (and saline) infusions at one dose rate: 0.04 microg . h-1 . kg body wt-1 (low), 0.08 microg . h-1 . kg-1 (medium), or 8.0 microg . h-1 . kg-1 (high). Low and medium melatonin infusions produced plasma and saliva levels within the normal nocturnal range observed in young adults. These levels were not associated with any changes in rectal, hand, forehead, or tympanic temperatures or with subjective sleepiness. High melatonin produced supraphysiological plasma and saliva levels and was associated with a significant attenuation in the daytime increase in rectal temperature, significantly increased hand temperature, and greater sleepiness. It is not yet clear whether the thermoregulatory and soporific effects of daytime supraphysiological melatonin administration are equivalent to the physiological responses to endogenous melatonin.
机译：白天口服褪黑激素通常会产生促渗透作用和体温调节作用。然而，尚不清楚这些作用是否反映出对内源性夜间褪黑激素产生的正常生理反应。在两天的卧床休息方案中，我们以在24位年轻人中产生生理和生理上稳态水平的剂量注入褪黑激素。从1000到1630年，受试者以平衡的方式静脉注射生理盐水或褪黑激素。八名受试者的每组以一种剂量率：0.04 microg接受褪黑激素（和盐水）输注。 h-1体重kg-1（低），0.08微克。 h-1 kg-1（中），或8.0 microg。 h-1 kg-1（高）。在年轻人中观察到的低和中度褪黑素输注产生的血浆和唾液水平在正常的夜间范围内。这些水平与直肠，手，前额或鼓膜温度的任何变化或主观嗜睡无关。褪黑激素高会产生血浆和唾液的超生理水平，并与白天直肠温度的明显升高，手部温度的显着升高和更大的嗜睡现象有关。尚不清楚白天超生理褪黑激素给药的温度调节和治疗效果是否等同于对内源性褪黑激素的生理反应。

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