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首页> 外文期刊>American Journal of Physiology >Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.
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Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.

机译：Eotaxin / CCL11参与了对烟曲霉的急性但非慢性变应性气道反应。

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摘要

Eotaxin/CCL11 is a major chemoattractant for eosinophils and Th2 cells. As such, it represents an attractive target in the treatment of allergic disease. The present study addresses the role of eotaxin/CCL11 during acute and chronic allergic airway responses to the fungus Aspergillus fumigatus. Mice lacking the eotaxin gene (Eo-/-) and wild-type mice (Eo+/+) were sensitized to A. fumigatus and received either an intratracheal challenge with soluble A. fumigatus antigens (acute model) or an intratracheal challenge with live A. fumigatus spores or conidia (chronic model). Airway hyperresponsiveness and eosinophil, but not T cell, recruitment were significantly decreased at 24 h after the soluble allergen in A. fumigatus-sensitized Eo-/- mice compared with similarly sensitized Eo+/+ mice. In contrast, the development of chronic allergic airway disease due to A. fumigatus conidia was not altered by the lack of eotaxin. Together, these data suggest that eotaxin initiates allergic airway disease due to A. fumigatus, but this chemokine did not appear to contribute to the maintenance of A. fumigatus-induced allergic airway disease.
机译：嗜酸性粒细胞趋化因子/ CCL11是嗜酸性粒细胞和Th2细胞的主要化学引诱剂。这样，它代表了变应性疾病治疗中有吸引力的靶标。本研究探讨了嗜酸性粒细胞趋化因子/ CCL11在真菌对烟曲霉的急性和慢性过敏性气道反应中的作用。缺乏嗜酸性粒细胞趋化因子基因（Eo-/-）的小鼠和野生型小鼠（Eo + / +）对烟曲霉敏感，并接受气管内挑战性烟曲霉抗原（急性模型）或气管内挑战性活烟曲霉烟熏孢子或分生孢子（慢性模型）。与敏感致敏的Eo + / +小鼠相比，烟曲霉致敏的Eo-/-小鼠的可溶性变应原在24 h后，气道高反应性和嗜酸性粒细胞（而非T细胞）募集显着降低。相反，缺乏烟曲霉不会改变由烟曲霉分生孢子引起的慢性过敏性气道疾病的发生。总之，这些数据表明，嗜酸性粒细胞趋化因子引发了由于烟曲霉引起的过敏性气道疾病，但是这种趋化因子似乎并未有助于维持烟曲霉引起的过敏性气道疾病。

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