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首页> 外文期刊>American Journal of Physiology >Sialyl Lewis(x) hybridized complement receptor type 1 moderates acid aspiration injury.
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Sialyl Lewis(x) hybridized complement receptor type 1 moderates acid aspiration injury.

机译：唾液酸化的Lewis（x）杂交补体受体1型可减轻酸吸入损伤。

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摘要

The potentially enhanced anti-inflammatory effects of the sialyl Lewis(x) (sLe(x))-decorated version of soluble complement receptor type 1 (sCR1) in moderating acid aspiration injury are examined. HCl was instilled in tracheostomy tubes placed in mice, and extravasation of (125)I-labeled albumin in bronchoalveolar lavage (BAL) fluid was used to calculate the vascular permeability index (PI). Neutrophil counts in BAL fluid and immunohistochemistry were performed. PI was moderated by 82% after treatment with sCR1sLe(x) compared with 54% in sCR1-untreated mice (P < 0.05). Respective reductions in PI in mice treated 0.5 and 1 h after acid aspiration with sCR1sLe(x) of 70 and 57% were greater than the decreases in PI of 45 and 38% observed in respective sCR1-treated groups (P < 0.05). BAL fluid neutrophil counts in sCR1sLe(x)-treated mice were significantly less than those in sCR1-treated animals, which were similar to those in untreated mice. Immunohistochemistry stained for sCR1 only on the pulmonary vascular endothelium of sCR1sLe(x)- but not sCR1-treated mice. In conclusion, sCR1sLe(x) moderates permeability by antagonizing complement activation and neutrophil adhesion. Delayed complement and neutrophil antagonism significantly reduces injury.
机译：审查了唾液酸路易斯（x）（sLe（x））装饰的可溶性补体受体1型（sCR1）在减轻酸吸入损伤中的潜在增强的抗炎作用。将HCl注入放置在小鼠中的气管造口管中，并用支气管肺泡灌洗（BAL）液中（125）I标记的白蛋白外渗来计算血管渗透指数（PI）。进行BAL液中的嗜中性粒细胞计数和免疫组化。用sCR1sLe（x）治疗后，PI降低了82％，而未治疗sCR1的小鼠则降低了54％（P <0.05）。 sCR1sLe（x）分别为70％和57％的酸抽吸后0.5和1 h处理的小鼠中，PI的降低幅度分别大于分别经sCR1治疗组的PI的45和38％的降低（P <0.05）。 sCR1sLe（x）治疗的小鼠中的BAL液体中性粒细胞计数显着低于sCR1治疗的动物，与未治疗的小鼠相似。免疫组化仅在sCR1sLe（x）-的肺血管内皮上对sCR1染色，但未对sCR1处理的小鼠染色。总之，sCR1sLe（x）通过拮抗补体激活和嗜中性粒细胞粘附来调节通透性。延迟补体和中性粒细胞拮抗作用可显着减少损伤。

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