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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Comparison of Effects of Low-Flow Sevoflurane and Desflurane Anesthesia on Neutrophil and T-Cell Populations
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Comparison of Effects of Low-Flow Sevoflurane and Desflurane Anesthesia on Neutrophil and T-Cell Populations

机译：低流量七氟醚和地氟烷麻醉对中性粒细胞和T细胞群体影响的比较

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BACKGROUND: Numerous transient effects of anesthesia on postoperative immune status have been documented in the literature.OBJECTIVE: This study was performed to test the hypothesis that the effects on neutrophil and T-cell populations differ with use of low-flow sevoflurane- and desflurane-induced anesthesia during abdominal surgery.METHODS: Fifty adult patients (American Society of Anesthesiologists physical status I or II) aged 20 to 60 years were recruited for the study. Patients were randomly assigned to one of two study groups. Anesthesia was induced using fentanyl, propofol, and vecuronium. After intubation, patients in group 1 received sevoflurane, oxygen, and nitrous oxide at a flow rate of 6 L/min, and those in group 2 received desflurane, oxygen, and nitrous oxide at a flow rate of 6 L/min. Ten minutes after induction of anesthesia, the flow rate was decreased to 1 L/min in both groups. Total leukocyte, lymphocyte, and neutrophil counts, percentage of T helper lymphocytes (CD4), cytotoxic T lymphocytes (CD8), natural killer lymphocytes, and active T lymphocyte, CD4/CD8 ratio, and plasma cortisol values were assessed before and at 2 and 24 hours after induction of anesthesia.RESULTS: In the desflurane group, at 2 hours after induction of anesthesia, a significant decrease was observed in the lymphocyte count, percentage of CD4 cells, and CD4/CD8 ratio, and a significant increase was noted in the neutrophil count and percentage of CD8 cells (P < 0.05). At 24 hours after induction of anesthesia, a significant increase was observed in the leukocyte and neutrophil counts, percentage of CD4 cells, and CD4/CD8 ratio (P < 0.05). There was no change in the other parameters studied. In the sevoflurane group, a significant decrease was observed in the lymphocyte count and percentage of natural killer cells. In addition, a significant increase was noted in the leukocyte and neutrophil counts at 24 hours after induction of anesthesia (P < 0.01). The increase in the neutrophil count in the desflurane group compared with that in the sevoflurane group was statistically significant (P < 0.05).CONCLUSIONS: With use of the low-flow anesthesia technique, compared with desflurane, sevoflurane exerts minimal effects on neutrophil and T-cell populations, which supports our hypothesis.
机译：背景：文献报道了麻醉对手术后免疫状态的许多短暂影响。方法：招募了五十名年龄在20至60岁之间的成年患者（美国麻醉医师学会I或II身体状况）。将患者随机分配至两个研究组之一。使用芬太尼，丙泊酚和维库溴铵诱导麻醉。插管后，第1组的患者以6 L / min的流速接受七氟醚，氧气和一氧化二氮，第2组的患者以6 L / min的流速接受地氟醚，氧气和一氧化二氮。麻醉诱导后十分钟，两组流速均降低至1 L / min。分别在2和2之前和之后评估了白细胞，淋巴细胞和中性粒细胞总数，T辅助淋巴细胞（CD4），细胞毒性T淋巴细胞（CD8），天然杀伤性淋巴细胞和活性T淋巴细胞的百分比，CD4 / CD8比值和血浆皮质醇值。结果：麻醉诱导后24小时。地氟醚组在诱导麻醉后2小时，淋巴细胞计数，CD4细胞百分比和CD4 / CD8比值显着下降，并且CD8细胞的中性粒细胞计数和百分比（P <0.05）。麻醉诱导后24小时，白细胞和中性粒细胞计数，CD4细胞百分比和CD4 / CD8比值显着增加（P <0.05）。研究的其他参数没有变化。在七氟醚组中，淋巴细胞计数和自然杀伤细胞百分比显着下降。此外，在麻醉诱导后24小时白细胞和嗜中性粒细胞计数显着增加（P <0.01）。与七氟醚组相比，地氟醚组中性粒细胞计数的增加具有统计学意义（P <0.05）。结论：使用低流量麻醉技术，与地氟醚相比，七氟醚对中性粒细胞和T的影响最小。细胞群体，这支持了我们的假设。

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