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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Possible.Therapeutic Effect of Trilostane in Rodent Models of Inflammation and Nociception
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Possible.Therapeutic Effect of Trilostane in Rodent Models of Inflammation and Nociception

机译：Trilostane在啮齿类动物炎症和伤害感受中的治疗作用

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Background: Trilostane was identified in an in vivo screen of compounds in a lipopolysaccharide model of inflammation to support a repurposing effort. There is no previous documentation of any anti-inflammatory effects of trilostane.Objective: The aim of this study was to elucidate the novel pharmacologic activity of trilostane in a series of inflammation and nociception signal-finding models.Methods: Anti-inflammatory effects of trilostane were evaluated in lipopolysaccharide-induced systemic and lung inflammation models and in a 2,4-dinitrofluorobenzene-induced delayed-type hypersensitivity (DTH) model in the mouse ear. The analgesic activities of trilostane were evaluated in a hot plate nociception model as a function of paw-withdrawal latency and in the formalin-induced nociception model with a behavioral end point. In all studies, trilostane was administered 15 minutes before challenge. In the DTH model, the animals were given a second dose 24 hours after the first dose. Results: Trilostane inhibited tumor necrosis factor-alpha and monocyte chemoattractant protein-1 production in the lipopolysaccharide-induced systemic and pulmonary inflammation models. It also significantly reduced ear swelling in the 2,4-dinitrofIuorobenzene-induced DTH model. In the hot plate nociception model, trilostane increased the latency of paw-licking behavior. Trilostane also significantly reduced the duration of pain behaviors in the late phase of the formalin-induced inflammatory pain model. Conclusions: These signal-finding studies suggest that trilostane has novel anti-inflammatory and analgesic properties.
机译：背景：在体内脂多糖炎症模型的化合物的体内筛选中鉴定出了三氯杀螨醇，以支持重新努力。以前尚无有关Trilostane的抗炎作用的文献。目的：本研究的目的是阐明Trilostane在一系列炎症和伤害感受信号查找模型中的新药理活性。方法：Trilostane的抗炎作用在小鼠耳朵中，脂多糖诱导的全身和肺部炎症模型以及2,4-二硝基氟苯诱导的迟发型超敏反应（DTH）模型中进行了评估。在热板伤害感受模型中，根据爪退缩潜伏期和在福尔马林诱导的伤害感受模型中以行为终点评估了三氯杀螨醇的镇痛活性。在所有研究中，均在攻击前15分钟施用三氯杀e。在DTH模型中，在第一剂后24小时给动物第二剂。结果：Trilostane在脂多糖诱导的全身和肺部炎症模型中抑制了肿瘤坏死因子-α和单核细胞趋化蛋白1的产生。在2，4-二硝基氟苯诱导的DTH模型中，它也显着降低了耳朵肿胀。在热板伤害感受模型中，三氯杀螨醇增加了舔足行为的潜伏期。在福尔马林诱导的炎性疼痛模型的晚期，曲洛司汀也显着减少了疼痛行为的持续时间。结论：这些信号发现研究表明，三氯杀螨醇具有新颖的抗炎和镇痛作用。

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