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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Fondapannux Versus Nadropann for Prevention of Venous Thromboembohsm After Elective Hip and Knee Arthroplasty
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Fondapannux Versus Nadropann for Prevention of Venous Thromboembohsm After Elective Hip and Knee Arthroplasty

机译：Fondaparinux与Nadropann预防髋部和膝关节置换术后静脉血栓栓塞

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Objective: To evaluate the efficacy and safety of fondaparinux compared with nadroparin for prevention of venous thromboembolism after arthroplasty.Patients and methods: One hundred fifteen patients were randomized into 2 treatment groups. Patients were given fondaparinux in Group I and nadroparin in Group II. Measurements were performed on Days 1, 5, and 21. The wound area was assessed with a subjective visual analog scale. Results: The blood counts, clinical biochemical tests, and coagulation tests (ie, thrombin time, partial thromboplastin time, activated partial thromboplastin time, fibrinogen, prothrombin time-International Normalized Ratio, and antithrombin III activity) did not show statistically significant differences between Group I and Group II. In both study groups, anti-factor Xa activities increased significantly on the fifth and 21st day. The scores of the subjective visual analog scale showed significance on Day 21.Conclusions: Our results confirm the safety and efficacy of both fondaparinux and nadroparin for prophylaxis after major orthopedic surgery.
机译：目的：评价磺达肝癸钠与萘达普林比较预防关节置换术后静脉血栓栓塞的疗效和安全性。方法与方法：将115例患者随机分为2个治疗组。在第一组中给患者服用磺达肝素，第二组中给患者服用萘达帕林。在第1、5和21天进行测量。用主观视觉模拟量表评估伤口面积。结果：血细胞计数，临床生化检查和凝血检查（即凝血酶时间，凝血酶原时间，活化凝血酶原时间，纤维蛋白原，凝血酶原时间-国际标准化比率和抗凝血酶III活性）在两组之间无统计学差异。我和第二组。在两个研究组中，抗因子Xa活性在第5天和第21天均显着增加。主观视觉模拟量表的评分在第21天显示出重要意义。结论：我们的结果证实了fondaparinux和nadroparin预防大骨科手术后的安全性和有效性。

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