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首页> 外文期刊>Aging cell. >Intraspecific variation in survival and mitochondrial oxidative phosphorylation in wild-caught Drosophila simulans.
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Intraspecific variation in survival and mitochondrial oxidative phosphorylation in wild-caught Drosophila simulans.

机译：野生捕获的果蝇模拟物中的生存和线粒体氧化磷酸化的种内变异。

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摘要

Lifespans of organisms vary greatly even among individuals of the same species. Under the framework of the free oxygen radical theory of aging, it is predicted that variation in individual lifespan within a species will correlate with variation in the accumulation of oxidative damage to cell components from reactive oxygen species. In this study we test the hypothesis that variation in survival of three wild-caught Drosophila simulans fly lines (HW09, NC48 and MD106) correlates with three key aspects of mitochondrial bioenergetics. The rank order of median survival was HW09 > MD106 > NC48. Young HW09 flies (11-18 days) had (i) highest ADP:O (quantity of oxygen consumed by mitochondria when provided with a quantity of ADP) when metabolizing both electron transport chain complex I and complex III substrates; (ii) lowest rate of mitochondrial hydrogen peroxide production from complex III; and (iii) highest cytochrome c oxidase activity from complex IV. Rate of hydrogen peroxide production increased and cytochrome c oxidase activity decreased in all lines in the age range 11-25 days. This is the first study to correlate natural variation in organism survival with natural variation in mitochondrial bioenergetics.
机译：即使在同一物种的个体之间，生物的寿命差异也很大。在衰老的游离氧自由基理论的框架下，预计物种内个体寿命的变化将与活性氧对细胞成分的氧化损伤积累的变化相关。在这项研究中，我们测试了以下假设：三种野生果蝇模拟蝇（HW09，NC48和MD106）存活线的变异与线粒体生物能学的三个关键方面相关。中位生存期的排名顺序是HW09> MD106> NC48。年轻的HW09苍蝇（11-18天）在代谢电子传输链复合物I和复合物III底物时具有最高的ADP：O（当线粒体提供一定量的ADP时，线粒体消耗的氧气量）; （ii）从复合物III产生线粒体过氧化氢的最低速率; （iii）来自复合物IV的最高细胞色素c氧化酶活性。在所有年龄在11-25天的品系中，过氧化氢的产生速率增加，细胞色素c氧化酶活性降低。这是第一项将生物体生存的自然变化与线粒体生物能学的自然变化相关联的研究。

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