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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Ankaferd Blood Stopper Is More Effective Than Adrenaline Plus Lidocaine and Gelatin Foam in the Treatment of Epistaxis in Rabbits
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Ankaferd Blood Stopper Is More Effective Than Adrenaline Plus Lidocaine and Gelatin Foam in the Treatment of Epistaxis in Rabbits

机译：Ankaferd止血剂比肾上腺素加利多卡因和明胶泡沫在治疗鼻出血方面更有效

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BACKGROUND: Epistaxis is an important emergency that can sometimes be life threatening without effective intervention. Persistent and recurrent bleeding can lead to aspiration, hypotension, hypoxia, or even severe and mortal cardiovascular complications. Providing prompt hemostasis is important, and the hemostatic method used must be easily and locally applicable, efficient, and inexpensive.OBJECTIVE: The aim of this study was to assess the hemostatic efficacy of Ankaferd Blood Stopper (ABS) in an experimental epistaxis model and to determine the histopathologic alterations with topical ABS application.METHODS: Twenty-eight New Zealand rabbits were evaluated in 4 study groups. Topical ABS, gelatin foam (GF), adrenalin + lidocaine (AL), and serum physiologic as negative control (C) were applied to the animals for controlling epistaxis. The bleeding was generated with a standard mucosal incision in all groups. Cotton pieces soaked with ABS, AL, C, and GF were applied to the nasal bleeding area. Time of hemostasis was recorded. Tissue samples were obtained after hemostasis for histopathologic examination. The samples were stained with hematoxylin and eosin (HE) and phosphotungstic acid hematoxylin (PTAH) and were examined under a light microscope. In this experimental study, the observers were blind to ABS, AL, and C but not to GF, because of its solid nature.RESULTS: Median durations required for hemostasis in ABS, AL, GF, and C groups were recorded as 30, 90, 90, and 210 seconds, respectively. The time until termination of bleeding in the ABS group was significantly shorter than that in the AL, GF, and C groups (P = 0.002, P = 0.002, and P = 0.001, respectively). On histopathologic evaluation, after staining with HE, minimal fibrin at the incision edges and a few extravasated erythrocytes were observed in the C, AL, and GF groups. In the ABS group, a dark amorphous material surrounded by fibrin, filling the space between the edges of incisions, was noticed. Fibrin...
机译：背景：鼻出血是一项重要的紧急事件，如果没有有效的干预，有时可能会危及生命。持续不断的出血会导致误吸，低血压，缺氧，甚至导致严重的致命性心血管并发症。提供迅速的止血非常重要，并且所使用的止血方法必须易于本地应用，有效且廉价。方法：在4个研究组中对28只新西兰兔进行了评估。将局部ABS，明胶泡沫（GF），肾上腺素+利多卡因（AL）和血清生理学用作阴性对照（C），以控制鼻epi。所有组均通过标准的粘膜切口产生出血。将经ABS，AL，C和GF浸透的棉片用于鼻腔出血区域。记录止血时间。止血后获取组织样品用于组织病理学检查。样品用苏木精和曙红（HE）和磷钨酸苏木精（PTAH）染色，并在光学显微镜下检查。在这项实验研究中，观察者对ABS，AL和C视而不见，但对GF视而不见。结果：ABS，AL，GF和C​​组止血所需的中位持续时间分别记录为30、90 ，分别为90和210秒。 ABS组止血的时间明显短于AL，GF和C​​组（分别为P = 0.002，P = 0.002和P = 0.001）。在组织病理学评估中，HE染色后，在C，AL和GF组中观察到切口边缘的纤维蛋白最少，并且观察到少量外渗红细胞。在ABS组中，发现了由纤维蛋白包围的深色无定形物质，填充了切口边缘之间的空间。纤维蛋白...

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