• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current therapeutic research, clinical and experimental. >Growth Hormone for Intestinal Adaptation in Patients With Short Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials
【24h】

Growth Hormone for Intestinal Adaptation in Patients With Short Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials

机译：短肠综合征患者肠道适应的生长激素：随机对照试验的系统评价和荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: The purpose of this systematic review was to assess the efficacy of growth hormone (GH) treatment in patients with short bowel syndrome (SBS).METHODS: Electronic searches were performed to identify all publications describing randomized controlled trials (RCTs) on the use of GH with or without glutamine for the treatment of patients with SBS. The outcomes of interest were body weight, lean body mass, and intestinal absorption function.RESULTS: Four trials involving 70 patients were included in the review. A meta-analysis of these trials suggested that GH had a positive effect in terms of increased weight (mean difference [MD} = 1.66; 95% CI, 0.69-2.63, P < 0.001), lean body mass (MD = 1.93; 95% CI, 0.97-2.90; P < 0.001), energy absorption (MD = 4.42; 95% CI, 0.26-8.58; P = 0.04), nitrogen absorption (MD = 4.85; 95% CI, 0.20-9.49; P = 0.04), and fat absorption (MD = 5.02; 95% CI, 0.21-9.82; P = 0.04) for patients with SBS. Adverse effects occurred during active treatment in all trials. Only 1 trial included a 12-week follow-up study.CONCLUSIONS: The results suggest a possible short-term benefit in terms of body weight, lean body mass, and absorptive capacities; however, no conclusion of long-term efficacy of GH could be obtained. Large-scale, long-term follow-up RCTs are needed to confirm the efficacy and tolerability of GH in the future.
机译：目的：本系统综述的目的是评估生长激素（GH）在短肠综合征（SBS）患者中的疗效。方法：进行电子搜索以鉴定所有描述使用随机对照试验（RCT）的出版物。有或没有谷氨酰胺的GH治疗SBS患者。感兴趣的结果是体重，瘦体重和肠道吸收功能。结果：纳入了涉及70例患者的四项试验。对这些试验的荟萃分析表明，GH在体重增加（平均差异[MD} = 1.66; 95％CI，0.69-2.63，P <0.001），瘦体重（MD = 1.93; 95）方面具有积极作用％CI，0.97-2.90; P <0.001），能量吸收（MD = 4.42; 95％CI，0.26-8.58; P = 0.04），氮吸收（MD = 4.85; 95％CI，0.20-9.49; P = 0.04 ）和SBS患者的脂肪吸收（MD = 5.02; 95％CI，0.21-9.82; P = 0.04）。在所有试验中，积极治疗期间均出现不良反应。只有1个试验包括一项为期12周的随访研究。结论：结果表明，在体重，瘦体重和吸收能力方面可能有短期益处。然而，无法获得GH长期疗效的结论。需要大规模，长期的后续RCT，以确认GH的疗效和耐受性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号