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首页> 外文期刊>Aging clinical and experimental research >Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment.
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Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment.

机译：老年原发性高血压患者血液中一氧化氮的产生，脂质过氧化作用和铜蓝蛋白的氧化酶活性培哚普利治疗的效果。

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BACKGROUND AND AIMS: One of the factors playing a role in both the aging process and the etiopathogenesis of primary hypertension is oxidative stress. The purpose of this work was to estimate the production of nitric oxide (NO), oxidase activity of ceruloplasmin (Cp) and level of malondialdehyde (MDA), the end-product of lipid peroxidation in the blood of elderly patients with primary hypertension. The influence of treatment with the angiotensin-converting enzyme inhibitor perindopril (P) on the above parameters was also ascertained. METHODS: The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2). Cp oxidase activity in serum, MDA level expressed as the concentration of substances reacting to thiobarbituric acid in red blood cells, and production of NO (concentration of nitriteitrate in plasma) by the Griess reaction were all determined. RESULTS: In the group of patients with hypertension, Cp activity was significantly higher than that in the control groups (K1 and K2). MDA concentrations in the erythrocytes of patients with hypertension were significantly higher than in the control groups and hypertensive patients had a lower NO (nitriteitrate) levels in plasma when compared with controls. In patients with hypertension, after only 7 days of therapy a substantial decrease in Cp oxidative activity was found, although the lowest value was observed after 6 weeks of therapy. Nevertheless, significantly lower MDA was observed after 6 weeks of therapy, corresponding to the values obtained in controls (K1 and K2). After 6 weeks of perindopril therapy, NO (nitriteitrate) was statistically higher in comparison with the values obtained before therapy. CONCLUSIONS: Results confirm intensification of oxidative stress and disorders in the production of NO in elderly patients with primary hypertension, and indicate the beneficial antioxidant effect of P.
机译：背景与目的：在原发性高血压的衰老过程和发病机制中均起作用的因素之一是氧化应激。这项工作的目的是评估一氧化氮（NO）的产生，铜蓝蛋白（Cp）的氧化酶活性和丙二醛（MDA）的水平，丙二醛是老年原发性高血压患者血液中脂质过氧化的最终产物。还确定了用血管紧张素转化酶抑制剂培哚普利（P）处理对上述参数的影响。方法：本研究针对37名原发性高血压患者（69-91岁），培哚普利治疗6周以及血压正常的受试者组成，这两个对照组分别为25名（65-96岁-K1）和23名（ 22-41岁-K2）。测定了血清中的Cp氧化酶活性，表示为与红细胞中与硫代巴比妥酸反应的物质的浓度的MDA水平以及通过Griess反应产生的NO（血浆中亚硝酸盐/硝酸盐的浓度）。结果：在高血压患者组中，Cp活性显着高于对照组（K1和K2）。与对照组相比，高血压患者红细胞中的MDA浓度明显高于对照组，而高血压患者血浆中的NO（亚硝酸盐/硝酸盐）水平较低。在高血压患者中，仅在治疗7天后Cp氧化活性显着下降，尽管在治疗6周后观察到最低值。尽管如此，治疗6周后仍观察到MDA明显降低，与对照组（K1和K2）中获得的值相对应。培哚普利治疗6周后，与治疗前相比，NO（亚硝酸盐/硝酸盐）在统计学上更高。结论：结果证实了老年原发性高血压患者中氧化应激的加剧和NO生成中的异常，并表明P具有有益的抗氧化作用。

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