OBJECTIVE: To determine cardiovascular effects of desflurane in mechanically ventilated calves. ANIMALS: 8 healthy male calves. PROCEDURE: Calves were anesthetized by face mask administration of desflurane to permit instrumentation. Administration of desflurane was temporarily discontinued until mean arterial blood pressure increased to &or= 100 mm Hg, at which time baseline cardiovascular values, pulmonary arterial temperature, end-tidal CO(2) tension, and end-tidal desflurane concentration were recorded. Cardiac index and systemic and pulmonary vascular resistances were calculated. Arterial blood gas variables were measured and calculated. Mean end-tidal concentration of desflurane at this time was 3.4%. After collection of baseline values, administration of 10% end-tidal concentration of desflurane was resumed and calves were connected to a mechanical ventilator. Cardiovascular data were collected at 5, 10, 15, 30, and 45 minutes, whereas arterial blood gas data were collected at 15 and 45 minutes after collection of baseline data. RESULTS: Mean +/- SD duration from beginning desflurane administration to intubation of the trachea was 151 +/- 32.8 seconds. Relative to baseline, desflurane anesthesia was associated with a maximal decrease in arterial blood pressure of 35% and a decrease in systemic vascular resistance of 34%. Pulmonary arterial blood temperature was decreased from 15 through 45 minutes, compared with baseline values. There were no significant changes in other measured variables. All calves recovered from anesthesia without complications. CONCLUSIONS AND CLINICAL RELEVANCE: Administration of desflurane for induction and maintenance of general anesthesia in calves was smooth, safe, and effective. Cardiopulmonary variables remained in reference ranges throughout the study period.
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机译：目的：测定地氟醚在机械通气小牛中的心血管作用。动物：8头健康的雄性犊牛。程序：通过面膜给予地氟醚麻醉小牛，以便进行器械检查。暂时停止使用地氟醚的给药，直到平均动脉血压增至≥100 mm Hg，此时记录基线心血管值，肺动脉温度，潮气末CO（2）张力和潮气末地氟醚浓度。计算心脏指数以及全身和肺血管阻力。测量和计算动脉血气变量。此时，地氟醚的潮气末平均浓度为3.4％。收集基线值后，恢复使用10％地氟醚的潮气末浓度，并将小牛连接到机械呼吸机。在第5、10、15、30和45分钟收集心血管数据，而在收集基线数据后第15和45分钟收集动脉血气数据。结果：从开始给予地氟烷至气管插管的平均+/- SD持续时间为151 +/- 32.8秒。相对于基线，地氟醚麻醉可使动脉血压最大降低35％，全身血管阻力降低34％。与基线值相比，肺动脉温度从15分钟降低到45分钟。其他测量变量没有显着变化。所有小牛均从麻醉中恢复，无并发症。结论和临床意义：地氟醚用于犊牛全身麻醉的诱导和维持是顺利，安全和有效的。在整个研究期间，心肺变量均保持在参考范围内。
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