...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Veterinary Research >Evaluation of plasma activity of matrix metalloproteinase-2 and -9 in dogs with myxomatous mitral valve disease
【24h】

Evaluation of plasma activity of matrix metalloproteinase-2 and -9 in dogs with myxomatous mitral valve disease

机译：粘液性二尖瓣疾病犬血浆中基质金属蛋白酶2和-9的血浆活性评估

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective-To investigate whether plasma activity of matrix metalloproteinase (MMP)-2 and -9 was associated with severity of myxomatous mitral valve disease (MMVD) in dogs and to assess potential associations between MMP activity and dog characteristics, echocardiographic variables, systolic arterial blood pressure (SAP), heart rate, cardiac troponin I (cTnI) concentration, and C-reactive protein concentration.Animals-75 client-owned dogs.Procedures-Severity of MMVD was assessed by use of echocardiography. Plasma activity of latent (pro-MMP) and active MMP-2 and -9 was analyzed via zymography. Plasma concentration of cTnI was analyzed with a high-sensitivity cTnI assay, and C-reactive protein concentration was analyzed with a canine-specific ELISA.Results-Pro MMP-9, active MMP-9, and pro MMP-2 were detected, but active MMP-2 was not. No significant differences were found in MMP concentrations among the 4 MMVD severity groups. Activity of pro MMP-9 decreased with decreases in SAP and was higher in male dogs than in female dogs. Activity of MMP-9 decreased with increases in left ventricular end-systolic dimension and with decreases in SAP and cTnI concentration. Left ventricular end-systolic dimension was the variable most strongly associated with MMP-9 activity. No associations were found between the activity of pro MMP-2 and investigated variables.Conclusions and Clinical Relevance-Plasma MMP-9 activity decreased with increases in the end-systolic left ventricular internal dimension and decreases in SAP Hence, evaluation of MMP-9 activity has the potential to provide unique information about the myocardial remodeling process in dogs with MMVD. (Am J Vet Res 201172:1022-1028)
机译：目的-研究犬血浆中基质金属蛋白酶（MMP）-2和-9的血浆活性是否与粘液性二尖瓣疾病（MMVD）的严重程度相关，并评估MMP活性与狗特征，超声心动图变量，收缩期动脉血之间的潜在关联压力（SAP），心率，心脏肌钙蛋白I（cTnI）浓度和C反应蛋白浓度。动物75只自家狗。使用超声心动图评估MMVD的程序-严重性。潜在的血浆活性（pro-MMP）和活性MMP-2和-9通过酶谱分析。通过高灵敏度cTnI测定法分析血浆cTnI浓度，并通过犬特异性ELISA分析C反应蛋白浓度，结果检测到Pro MMP-9，活性MMP-9和pro MMP-2，但活动的MMP-2没有。在4个MMVD严重程度组之间，MMP浓度没有发现显着差异。 pro MMP-9的活性随SAP的降低而降低，雄性狗的活性高于雌性狗。 MMP-9的活性随左心室收缩末期尺寸的增加以及SAP和cTnI浓度的降低而降低。左心室收缩末期尺寸是与MMP-9活性最密切相关的变量。 MMP-2的活性与研究变量之间没有相关性。结论和临床相关性-血浆MMP-9的活性随收缩末期左心室内部尺寸的增加而降低，SAP的降低，因此，对MMP-9活性的评价有潜力提供有关MMVD犬心肌重塑过程的独特信息。 （Am J Vet Res 201172：1022-1028）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号