...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Veterinary Research >Comparison of efficacy and duration of effect on corneal sensitivity among anesthetic agents following ocular administration in clinically normal horses
【24h】

Comparison of efficacy and duration of effect on corneal sensitivity among anesthetic agents following ocular administration in clinically normal horses

机译：临床正常马眼内麻醉后麻醉剂对角膜敏感性的疗效和作用时间的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective-To compare efficacy and duration of effect on corneal sensitivity of 0.5% proparacaine hydrochloride, 0.5% bupivacaine hydrochloride, 2% lidocaine hydrochloride, and 2% mepivacaine hydrochloride solutions following ocular administration in clinically normal horses. Animals-68 clinically normal horses. Procedures-60 horses were assigned to receive 1 anesthetic agent in 1 eye. For each of another 8 horses, 1 eye was treated with each of the anesthetic agents in random order with a 1-week washout period between treatments. Corneal sensitivity was assessed via corneal touch threshold (CTT) measurements obtained with a Cochet-Bonnet aesthesiometer before and at 1 minute, at 5-minute intervals from 5 to 60 minutes, and at 10-minute intervals from 60 to 90 minutes after application of 0.2 mL of anesthetic agent. General linear mixed models were fitted to the CTT data from each of the 2 experimental groups to assess the effects of the anesthetic agents over time, accounting for repeated observations within individual horses. Results-Corneal sensitivity decreased immediately following topical application of each anesthetic agent; effects persisted for 35 minutes for proparacaine and mepivacaine treatments, 45 minutes for lidocaine treatment, and 60 minutes for bupivacaine treatment. Maximal CTT reduction was achieved following application of bupivacaine or proparacaine solution, whereas mepivacaine solution was least effective. Conclusions and Clinical Relevance-Ocular application of each evaluated anesthetic agent reduced corneal sensitivity in horses; although 0.5% proparacaine or 2% lidocaine solution appeared to induce adequate short-duration corneal anesthesia, use of 0.5% bupivacaine solution may be more appropriate for procedures requiring longer periods of corneal anesthesia. (Am J Vet Res 2013;74:459-464)
机译：目的-比较临床上正常马眼中0.5％盐酸普罗卡因，0.5％布比卡因，2％盐酸利多卡因和2％盐酸米比卡因溶液对角膜敏感性的疗效和持续时间。 Animals-68临床上正常的马匹。将60匹马分配给1只眼接受1种麻醉剂。对于另外8匹马中的每匹，随机用每种麻醉剂对1只眼睛进行治疗，两次治疗之间的清洗期为1周。使用Cochet-Bonnet麻醉仪之前和之后1分钟，5分钟至60分钟的5分钟间隔以及60分钟至90分钟的10分钟间隔通过角膜接触阈值（CTT）测量评估角膜敏感性。 0.2 mL麻醉剂。将一般线性混合模型拟合到来自两个实验组中每一个的CTT数据，以评估麻醉剂随时间的作用，这说明了在个别马匹中的反复观察。结果-局部应用每种麻醉剂后，角膜敏感性立即降低;普罗卡因和甲哌卡因的治疗持续35分钟，利多卡因治疗持续45分钟，布比卡因治疗持续60分钟。应用布比卡因或普罗卡因溶液后可最大程度地降低CTT，而美比卡因溶液效果最差。结论和临床意义-每种评估麻醉剂的眼部应用均降低了马的角膜敏感性。尽管0.5％的普罗卡因或2％的利多卡因溶液似乎可以引起足够的短时间角膜麻醉，但0.5％的布比卡因溶液对于需要较长时间角膜麻醉的手术可能更合适。 （Am J Vet Res 2013; 74：459-464）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号