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首页> 外文期刊>American Journal of Ophthalmology: The International Journal of Ophthalmology >Bacteriologic profile of the conjunctiva in the patients with dry eye.
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Bacteriologic profile of the conjunctiva in the patients with dry eye.

机译：干眼症患者结膜的细菌学特征。

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PURPOSE: To assess the conjunctival bacterial profiles in dry eye and their fluoroquinolone susceptibility patterns. DESIGN: Prospective, observational study. METHODS: Sixty-seven female patients with dry eye (29 with Sjogren syndrome and 38 without Sjogren syndrome) who received artificial tears were enrolled at Osaka University Hospital in Japan. Twenty-three patients received additional topical steroids. Twenty-six puncta were occluded with plugs. Cultures were obtained with conjunctival swabs at the right eye of the subjects. The minimum inhibitory concentrations of isolated strains were determined for the fluoroquinolones (levofloxacin and gatifloxacin). The profiles of conjunctival bacteria of patients with dry eye were compared with those obtained before surgery from 56 female control patients. RESULTS: Eighty-eight strains were isolated (48 strains of Propionibacterium acnes, 26 coagulase-negative Staphylococcus [CNS] species, six Staphylococcus aureus strains, and eight others). Of the 26 CNS strains, 17 (65.4%) were fluoroquinolone resistant, including four (33.3%) of 12 methicillin-sensitive CNS and 13 (92.9%) of 14 methicillin-resistant CNS. All methicillin-sensitive S. aureus strains and P. acnes strains were sensitive to fluoroquinolones; one methicillin-resistant S. aureus strain was resistant. There was no significant difference in the conjunctival isolation rates between patients with dry eye and controls. However, the dry eye group had a significantly higher incidence of fluoroquinolone-resistant methicillin-sensitive CNS and of fluoroquinolone-resistant methicillin-resistant CNS than controls (P = .018 and P = .024, respectively). There were no significant differences in bacteria isolated between subgroups with or without punctal plugs and with or without topical steroids. CONCLUSIONS: Patients with dry eye are more likely to have fluoroquinolone-resistant conjunctival bacteria than controls. These results may help prevent infectious keratoconjunctivitis in patients with dry eye.
机译：目的：评估干眼结膜细菌的概况及其氟喹诺酮药敏感性模式。设计：前瞻性观察研究。方法：在日本大阪大学医院招募了67例接受人工泪液治疗的干眼女性患者（其中29例患有Sjogren综合征，38例没有Sjogren综合征）。 23名患者接受了额外的局部类固醇治疗。 26个小点被塞子塞住了。用受试者右眼的结膜拭子获得培养物。确定了氟喹诺酮类药物（左氧氟沙星和加替沙星）的最低分离菌株抑制浓度。将干眼患者的结膜细菌特征与手术前从56名女性对照患者获得的特征进行了比较。结果：分离到88株（痤疮丙酸杆菌48株，凝固酶阴性葡萄球菌[CNS] 26种，金黄色葡萄球菌6株，其他8株）。在26例CNS菌株中，有17例（65.4％）对氟喹诺酮耐药，包括4例（33.3％）的12种对甲氧西林敏感的CNS和13例（92.9％）的14种对甲氧西林的CNS。所有对甲氧西林敏感的金黄色葡萄球菌和痤疮丙酸杆菌菌株均对氟喹诺酮类药物敏感。一株耐甲氧西林的金黄色葡萄球菌具有耐药性。干眼症患者与对照组之间的结膜隔离率无显着差异。但是，干眼组的耐氟喹诺酮耐甲氧西林的中枢神经系统和耐氟喹诺酮耐甲氧西林的中枢神经系统的发生率明显高于对照组（分别为P = .018和P = .024）。在有或没有泪点塞和有或没有局部类固醇的亚组之间分离的细菌没有显着差异。结论：干眼患者比对照组患者更易患氟喹诺酮类结膜细菌。这些结果可能有助于预防干眼症患者的感染性角结膜炎。

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