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首页> 外文期刊>Amino acids >Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice
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Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice

机译：皮肤应用α-甲基亚精胺可激活小鼠静息毛囊的生长

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Recent studies using transgenic animals have revealed a crucial role for polyamines in the development and the growth of skin and hair follicles. In mammals, the growth of hair is characterized by three main cyclic phases of transformation, including a rapid growth phase (anagen), an apoptosis-driven regression phase (catagen) and a relatively quiescent resting phase (telogen). The polyamine pool during the anagen phase is higher than in telogen and catagen phases. In this study, we used α-methylspermidine, a meta-bolically stable polyamine analog, to artificially elevate the polyamine pool during telogen. This manipulation was sufficient to induce hair growth in telogen phase mice after 2 weeks of daily topical application. The application site was characterized by typical features of anagen, such as pigmentation, growing hair follicles, proliferation of follicular keratinocytes and upregulation of β-catenin. The analog penetrated the protective epidermal layer of the skin and could be detected in dermis. The natural polyamines were partially replaced by the analog in the application site. However, the combined pool of natural spermidine and α-methylspermidine exceeded the physiological spermidine pool in telogen phase skin. These results highlight the role of polyamines in hair cycle regulation and show that it is possible to control the process of hair growth using physiologically stable polyamine analogs.
机译：最近使用转基因动物的研究表明，多胺在皮肤和毛囊的发育和生长中起着至关重要的作用。在哺乳动物中，毛发生长的特征在于转化的三个主要循环阶段，包括快速生长阶段（生长期），细胞凋亡驱动的消退阶段（生长期）和相对静止的静止阶段（休止期）。在生长期中的多胺池比在静止期和催化期中的多胺池高。在这项研究中，我们使用α-甲基亚精胺（一种代谢稳定的多胺类似物）在端粒形成过程中人为地提高了多胺池。每天局部使用2周后，这种操作足以诱导毛发生长的小鼠。施用部位的特征是生长期的典型特征，例如色素沉着，毛囊生长，卵泡角质形成细胞增殖和β-连环蛋白上调。该类似物穿透了皮肤的保护性表皮层，可以在真皮中检测到。在施用部位，天然多胺被类似物部分取代。然而，天然亚精胺和α-甲基亚精胺的合并库超过了telogen期皮肤中的生理亚精库。这些结果突出了多胺在头发周期调节中的作用，并表明可以使用生理上稳定的多胺类似物来控制头发的生长过程。

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