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首页> 外文期刊>Anaesthesia and intensive care >Use of propofol infusion in Australian and New Zealand paediatric intensive care units.
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Use of propofol infusion in Australian and New Zealand paediatric intensive care units.

机译：在澳大利亚和新西兰的儿科重症监护病房使用丙泊酚输注。

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Despite the risk of propofol infusion syndrome, a rare but often fatal complication of propofol infusion in ventilated children and possibly adults, propofol infusion remains in use in paediatric intensive care units (PICU). This questionnaire study surveys the current pattern of use of this sedative infusion in Australian and New Zealand PICUs. Thirty-three of the 45 paediatric intensive care physicians surveyed (73%), from 12 of the 13 intensive care units, returned completed questionnaires. The majority of practitioners (82%) use propofol infusion in children in PICU, the main indication being for short-term sedation in children requiring procedures. 39% of respondents consider propofol infusion useful in ventilated children requiring longer-term sedation. 67% of paediatric intensivists use maximum infusion doses that may be considered dangerously high (> or = 10 mg/kg/h). Nineteen per cent use propofol infusion for prolonged periods (> 72 hours). A smaller proportion (15%) of respondents indicate that they may use both higher doses and prolonged periods of infusion, a practice likely to lead to a greater chance of serious adverse events. Knowledge of local protocols for the use of propofol infusion is associated with a significantly greater level of monitoring for possible adverse events. We suggest that national guidelines for the use of propofol infusion in children should be developed. These should include clear indications and contraindications to its use, a maximum dose rate and maximum period of infusion, with a ceiling placed on the cumulative dose given and clearly stated minimum monitoring requirements.
机译：尽管在通风良好的儿童甚至成人中存在异丙酚输注综合征的风险，这是罕见的但通常是致命的并发症，但儿科重症监护病房（PICU）仍在使用丙泊酚输注。这项问卷调查研究调查了在澳大利亚和新西兰的PICU中使用这种镇静剂的现状。在接受调查的45名儿科重症监护医师中，有33名（占13％）来自13个重症监护病房。在PICU中，大多数从业者（82％）使用丙泊酚输注，主要适应症是需要手术的儿童短期镇静。 39％的受访者认为丙泊酚输注可用于需要长期镇静的通气儿童。 67％的儿科强化医生使用最大输注剂量，这被认为是危险的高剂量（>或= 10 mg / kg / h）。 19％的患者长时间（> 72小时）使用异丙酚输注。较小比例的受访者（15％）表示他们可能同时使用较高的剂量和较长的输注时间，这种做法很可能导致发生严重不良事件的机会更大。对使用异丙酚输注的当地规程的了解与对可能的不良事件的监测水平明显更高有关。我们建议应制定有关在儿童中使用异丙酚输注的国家指南。这些应包括明确的使用指示和禁忌症，最大剂量率和最长输注时间，并以累计剂量为上限，并明确说明最低监测要求。

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