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首页> 外文期刊>Ageing Research Reviews >Redox proteomics and the dynamic molecular landscape of the aging brain
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Redox proteomics and the dynamic molecular landscape of the aging brain

机译：氧化还原蛋白质组学和衰老大脑的动态分子景观

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It is well established that the risk to develop neurodegenerative disorders increases with chronological aging. Accumulating studies contributed to characterize the age-dependent changes either at gene and protein expression level which, taken together, show that aging of the human brain results from the combination of the normal decline of multiple biological functions with environmental factors that contribute to defining disease risk of late-life brain disorders. Finding the "way out" of the labyrinth of such complex molecular interactions may help to fill the gap between "normal" brain aging and development of age-dependent diseases. To this purpose, proteomics studies are a powerful tool to better understand where to set the boundary line of healthy aging and age-related disease by analyzing the variation of protein expression levels and the major post translational modifications that determine "protein" physio/pathological fate. Increasing attention has been focused on oxidative modifications due to the crucial role of oxidative stress in aging, in addition to the fact that this type of modification is irreversible and may alter protein function. Redox proteomics studies contributed to decipher the complexity of brain aging by identifying the proteins that were increasingly oxidized and eventually dysfunctional as a function of age. The purpose of this review is to summarize the most important findings obtained by applying proteomics approaches to murine models of aging with also a brief overview of some human studies, in particular those related to dementia.
机译：众所周知，随着年龄的增长，发生神经退行性疾病的风险会增加。越来越多的研究有助于在基因和蛋白质表达水平上表征年龄相关的变化，这些变化合在一起显示，人脑衰老是由多种生物学功能的正常下降与有助于确定疾病风险的环境因素共同造成的晚期脑部疾病。找到这种复杂的分子相互作用的迷宫的“出路”可能有助于填补“正常”的大脑衰老和年龄依赖性疾病的发展之间的差距。为此，蛋白质组学研究是一种强大的工具，可通过分析蛋白质表达水平的变化和决定“蛋白质”生理/病理命运的主要翻译后修饰，来更好地了解健康衰老和与年龄相关疾病的界限。由于氧化应激在衰老中起关键作用，因此人们越来越关注氧化修饰，此外这种修饰是不可逆的并且可能改变蛋白质功能。氧化还原蛋白质组学研究通过识别随着年龄增长而逐渐氧化并最终功能失调的蛋白质，有助于破译大脑衰老的复杂性。这篇综述的目的是总结通过将蛋白质组学方法应用于衰老的鼠模型而获得的最重要的发现，并简要概述了一些人类研究，特别是与痴呆有关的研究。

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